Establishment of peak bone mineral density in Southern Chinese males and its comparisons with other males from different regions of China |
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Authors: | Li-Jun Tan Shu-Feng Lei Xiang-Ding Chen Man-Yuan Liu Yan-Fang Guo Hong Xu Xiao Sun Cheng Jiang Su-Mei Xiao Jing-Jing Guo Yan-Jun Yang Fei-Yan Deng Yan-Bo Wang Yuan-Neng Li Xue-Zhen Zhu Hong-Wen Deng |
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Institution: | (1) Laboratory of Molecular and Statistical Genetics and the Key Laboratory of Protein Chemistry and Developmental Biology of Ministry of Education, College of Life Sciences, Hunan Normal University, Changsha, Hunan, P. R. China;(2) Department of Orthopedic Surgery, School of Medicine, University of Missouri-Kansas City, Kansas City, MO, USA;(3) Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan, 410081, P. R. China |
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Abstract: | Peak bone mineral density (PBMD) is an important determinant of osteoporotic fracture and a precondition for correct diagnosis
of osteoporosis. The objective of this study was to establish the reference data of PBMD at the lumber spine and hip in Southern
Chinese males. Bone mineral density (BMD) was measured at the lumbar spine and hip (femoral neck, trochanter, intertrochanter,
and total) in 1155 Chinese men aged 15–39 years, using dual-energy X-ray absorptiometry (DXA). We utilized a fit curve method
to determine the best age range over which to calculate PBMD. Our results indicated that the PBMD was observed at the age
range of 18–25 years at the various sites. The mean value and standard deviation of PBMD was 0.753 ± 0.117, 1.156 ± 0.148,
0.896 ± 0.120, 0.989 ± 0.122, and 0.980 ± 0.116 g/cm2 at the trochanter, intertrochanter, femoral neck, total hip, and spine, respectively. When the present PBMD reference was
compared with the documented PBMD reference of males from other regions of China, we found great difference in standardized
PBMD between Changsha males and those from other regions of China. The PBMD for Chinese males in Changsha at the various sites
were 3.19%–11.33% lower than that for American Caucasian males. In conclusion, the PBMD at the spine and hip may be used as
normal reference data for Southern Chinese males in Changsha instead of documented PBMD from other regions of China and the
manufacturer's reference data. |
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Keywords: | Chinese male geographic difference peak bone mineral density reference data |
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