Serum bone gla-protein in osteoporosis treated with 1α-hydroxyvitamin D3 for more than five years |
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Authors: | Eiji Itoi Yuichiro Yamada Minoru Sakurai Kazutoshi Mizunashi Kozo Satoh Fumio Kasama |
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Institution: | (1) Department of Orthopaedic Surgery, Tohoku University School of Medicine, 1-1 Seiryo-cho, 980 Sendai, Japan;(2) The Second Department of Internal Medicine, Tohoku University School of Medicine, Japan;(3) Department of Orthopaedic Surgery, Akita University School of Medicine, 1-1 1-chome, Hondo, 010 Akita, Japan;(4) Department of Orthopaedic Surgery, Yonezawa Municipal Hospital 6-36 Aioi-cho, 992 Yonezawa, Japan |
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Abstract: | It has been reported that 1,25-dihydroxyvitamin D3 increases serum bone Gla-protein (BGP) in a short period in osteoporotic patients as well as in normal subjects. There have
been, however, no reports on serum BGP in osteoporotic patients under long term treatment with 1α-hydroxyvitamin D3. We measured serum BGP in 11 osteoporotic women treated with 1α-hydroxyvitamin D3 and calcium for 5–12 years, 8.4 years on average. Bone mineral density of distal radius was assessed by single photon absorptiometry.
Other biochemical parameters such as serum alkaline phosphatase, fasting urinary hydroxyproline/creatinine and calcium/creatinine
were also measured.
Serum BGP levels were 6.25±0.36ng/ml (mean±S.E.), being all within the normal range (6.2±3.86ng/ml). We found no significant
correlation between serum BGP and other biochemical parameters. Significant correlation was found neither between serum BGP
and period of treatment nor between serum BGP and bone mineral density.
Our result that serum BGP is within the normal range in osteoporotic patients whose bone mineral density has been maintained
by long-term treatment suggests the normal bone turnover in these patients. |
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Keywords: | bone Gla-protein (BGP) osteoporosis 1α -hydroxyvitamin D3 bone mineral density |
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