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苍白球腹后部切开术治疗帕金森病异动症的疗效分析
作者姓名:Zhao G  Li Y  Shao M  Ding Y
作者单位:首都医科大学宣武医院北京功能神经外科研究所!北京100053
摘    要:目的 分析苍白球腹后部切开术(PVP)对帕金森病(PD)患者中左旋多巴所诱导的异动症的治疗效果,评估手术的临床治疗意义。方法 采用国际上公认的PD综合评分法9UPDRS)对36例异动症患者的表现进行定量分,就异动症的持续时间、严重程度(致残度)以及整体影响做PVP术前术后的统计比较。结果 术后1周内症状的整体改善率为76.2%。其中手术对侧异动症持续时间减少88.8%;致残度改善79.7%。经统计

关 键 词:立体定位技术  苍白球切开  震颤性麻痹  PD

A clinical analysis of L-dopa induced dyskinesia treated by posteroventral pallidotomy for Parkinson's disease
Zhao G,Li Y,Shao M,Ding Y.A clinical analysis of L-dopa induced dyskinesia treated by posteroventral pallidotomy for Parkinson's disease[J].Chinese Journal of Surgery,1999,37(8):482-484.
Authors:Zhao G  Li Y  Shao M  Ding Y
Institution:Beijing Institute of Functional Neurosurgery, Beijing Xuanwu Hospital, Beijing 100053.
Abstract:OBJECTIVE: To evaluate the outcome of microelectrode-guided posteroventral pallidotomy (PVP) for L-dopa induced dyskinesia in patients with Parkinson's disease. METHODS: Thirty-six patients with dyskinesia were evaluated with unified Parkinson's disease rating scale (UPDRS) before and after operation. Duration and disability of dyskinesia were analyzed respectively. RESULTS: The total surgical improvement for dyskinesia was 76.2%. Duration improvement was 88.8% and disability 79.7%. Significant change (P < 0.05) happened postoperatively. Seventeen patients were followed up for 3 months. The result showed a stable improvement for dyskinesia. CONCLUSIONS: L-dopa induced dyskinesia may disappear or be improved after PVP. Surgical treatment promises a maximum L-dopa therapy without any severe pharmaceutical complications. Synergic treatment of drug and surgery are a new strategy for Parkinson's disease.
Keywords:Parkinson disease    Stereotaxic techniques    Globus palidus
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