胰腺癌血清肿瘤标记物联合检测的临床研究

目的：观察胰腺癌患者血清肿瘤标记物的表达，寻找对胰腺癌诊断与随访的有价值血清肿瘤标记物。方法：采用免疫分析法和放射免疫法检测92例胰腺癌患者的血清AFP、CEA、CA50、CA15－3、CA19－9、CA72－4、CA125和CA242共8种肿瘤标记物的表达，并与其它恶性肿瘤患者70例和良性疾病患者73例作对照，分析其临床诊断价值。结果：8种肿瘤标记物中CA19－9、CA242、CA50和CA125对胰腺癌诊断的相对价值较高，尤以CA19－9的诊断价值最高，灵敏度和特异度分别为82．6％和81．3％，平行法联合检测提高灵敏度至90．2％，系列法联合检测提高特异度93．5％，25例获手术切除者术后上述四项指标呈下降趋势。结论：血清CA19－9、CA242、CA50和CA125的检测对胰腺癌的诊断和随访是价值的，联合检测可以增加检测效率。

CLINICAL STUDY OF SERUM TUMOR MARKERS EXPESSION IN DIAGNOSIS AND PROG NOSIS OF PANCREATIC ADENOCARCINOMA

Objective To search the valuable serum tumor markers in diagnosis and prognosis of pancreatic carcinoma.Methods 8 kinds of serum tumor markers including AFP,CEA,CA50,CA15 3,CA19 9,CA72 4,CA125 and CA242 were detected in 92 patients with pancreatic carcinoma by Auto DELFIA and IRMA and in 70 patients with other malignant tumors,73 benign disease patients.25 patients after pancreatectomy were followed up.Results Among eight kinds of tumor markers,CA19 9,CA242,CA50 and CA125 were valuable in diagnosis of pancreatic carcinoma.CA19 9 was the most valuable one,its sensitivity and specificity were 82.6% and 81.3% respectively.After resection of the tumor,the 4 markers tended to decrease signficantly.Conclusion Serum CA19-9,CA242,CA50 and CA125 were valuable in diagnosis and following up of pancreatic carcinoma.