高血压患者血清基质金属蛋白酶9、基质金属蛋白酶抑制剂1、脂联素水平与白蛋白尿的关系

目的 探讨高血压患者血清基质金属蛋白酶9（MMP-9）、基质金属蛋白酶抑制剂1（TIMP-1）和脂联素（ADPN）的水平变化及其与白蛋白尿发生的相关性.方法 选择在我院进行体检的建筑工人175名,检测血压、尿常规、尿白蛋白肌酐比值（ACR）、血糖、血脂及肾功能,根据其血压和ACR分为健康对照组、单纯白蛋白尿组、单纯高血压组和高血压合并白蛋白尿组.测定各组受试者血清MMP-9、TIMP-1和ADPN水平,采用t检验进行数据分析.结果 与健康对照组比较,单纯高血压组及高血压合并白蛋白尿组血清MMP-9和TIMP-1水平明显升高（P＜ 0.05或P＜0.01）,高血压合并白蛋白尿组血清MMP-9水平较单纯高血压组明显升高（P＜0.05）,两组血清TIMP-1水平差异无统计学意义.与健康对照组比较,高血压合并白蛋白尿组血清ADPN水平明显下降（P＜0.05）.结论 高血压患者血清MMP-9和TIMP-1水平明显升高,MMP-9/TIMP-1平衡及血清ADPN可能参与高血压患者白蛋白尿的发生.

The relationship between serum matrix metallopeptidase 9, metallopeptidase inhibitor 1, adiponectin and albuminuria in hypertension patients

Objective To explore serum levels of matrix metalloproteinase-9 （MMP-9）, metallopeptidase inhibitor-1 （TIMP-1） and adiponectin （ADPN） and their correlation with albuminuria in hypertension patients. Methods A total of 175 adults who had health check-up in our center were enrolled in this investigation. All the subjects were tested for blood pressure, urinary albumin/creatinine ratio （ACR）, fasting glucose , lipoprotein and serum creatinine. The subjects were then assigned to the normal control, albuminuria, hypertension, hypertension ＋ albuminuria group, and serum MMP-9, TIMP-1 and ADPN were measured. Studnet＇ s t test was used for data anlysis. Results The serum levels of MMP-9 and TIMP-1 in hypertensive patients were significantly higher than those of the normal controls （ P 〈 0.05 or P 〈 0.01）. Serum MMP-9 in hyperteIlsion ＋ albuminuria group was higher than that of the hypertension group （ P 〈 0.05）. ADPN was significantly lower in hypertension ＋ albuminuria group （ P 〈 0.05）. Conclusion Serum MMP-9 and TIMP-1 may be in significandy increased in hypertensive patients. The balance of MMP- 9/I＇IMP-1 and senan ADPN could be involved in the pathogenesis of albuminuria in patients with hypertension.