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| Effect of human neural progenitor cells on injured spinal cord | |
| 作者姓名： | 徐光辉 白金柱 蔡钦林 李肖霞 李凌松 沈丽 |
| 作者单位： | Department of Orthopedics Zibo Central Hospital Zibo City 255036，Shandong Province，China，Department of Orthopedics，Third Affiliated Hospital Peking University Beijing 100083 China，Department of Orthopedics，Third Affiliated Hospital Peking University Beijing 100083 China，Stem Cell Research Center，Peking University Health Science Center，Peking University，Beijing 100082，China，Stem Cell Research Center，Peking University Health Science Center，Peking University，Beijing 100082，China，Stem Cell Research Center，Peking University Health Science Center，Peking University，Beijing 100082，China |
| 基金项目： | This study was supported by the National Basic Science andDevelopment Program (973 Project, No. 2001CB510100，863Project, No. 2001AA216171),a grant from Beijing Ministry ofScience and Technology ( No. 2002-489), and the ChineseDoctoral Foundation of Education Ministry (No. 200015). |
| 摘 要： | Human central nervous system ( CNS) has verylimited regenerative potentials. Patients withsevere injuries in the CNS such as spinal cordinjury (SCI) frequently endure lifelong disability. Avariety of methods have been tried to prevent spinalcord from further injury and foster regeneration afterSCI. Despite these efforts, an effective treatment forthis disease is still lacking. Since neural progenitorcells have already committed to become neural cells inthe CNS, they appear to be a good c… |
| 关 键 词： | 神经干细胞 脊髓损伤 治疗方法 临床表现 病理机制 |
| 收稿时间： | 2004-11-29 |
Effect of human neural progenitor cells on injured spinal cord |
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| XU Guang-hui,BAI Jin-zhu,CAI Qin-lin,LI Xiao-xia,LI Ling-song,SHEN Li.Effect of human neural progenitor cells on injured spinal cord[J].Chinese Journal of Traumatology(English Edition),2005,8(6):339-344. | |
| Authors: | XU Guang-hui BAI Jin-zhu CAI Qin-lin LI Xiao-xia LI Ling-song SHEN Li |
| Institution: | 1. Department of Orthopedics, Zibo Central Hospital, Zibo City 255036, Shandong Province , China 2. Department of Orthopedics, Third Affiliated Hospital,Peking University, Beijing 100083, China 3. Stem Cell Research Center, Peking University Health Science Center, Peking University, Beijing 100082, China |
| Abstract: | Objective: To study whether human neural progenitor cells can differentiate into neural cells in vivo and improve the recovery of injured spinal cord in rats. Methods: Human neural progenitor cells were transplanted into the injured spinal cord and the functional recovery of the rats with spinal cord contusion injury was evaluated with Basso-Beattie-Bresnahan (BBB) locomotor scale and motor evoked potentials. Additionally, the differentiation of human neural progenitor cells was shown by immunocytochemistry. Results: Human neural progenitor cells developed into functional cells in the injured spinal cord and improved the recovery of injured spinal cord in both locomotor scores and electrophysiological parameters in rats. Conclusions:Human neural progenitor cells can treat injured spinal cord, which may provide a new cell source for research of clinical application. |
| Keywords: | Stem cells Transplantation Cell differentiation Spinal cord injuries Evoked potentials motor |
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