肿瘤标记物联合检测在胰腺癌诊断及随访中的应用

目的评价血清学肿瘤标记物对胰腺癌诊断和随访的价值。方法对８５例胰腺癌病人和２０例慢性胰腺炎病人进行血清学肿瘤标记物检测，并利用其对１５例可切除胰腺癌病人进行随访。结果４种肿瘤标记物中以ＣＡ１９９敏感性和特异性最好，分别为７４．１１％和９０％，联合检测可提高其敏感性，达８９．４１％。胰腺癌切除术后６０％的病人肿瘤标记物降至正常，随访中再次升高表明有肿瘤复发或转移。结论肿瘤标记物联合检测有助于胰腺癌早期诊断，并可用于评价治疗效果、监测肿瘤复发和转移。

Application of combined assay of tumor markers in diagnosis and following up of pancreatic cancer

To evaluate the value of serum tumor markers in diagnosis and following up of pancreatic cancer. Method We detected tumor markers CA199, CA242, CA50 and CEA in 85 patients with pancreaticcancer and 20 patients with chronic pancreatitis, and utilized these markers to follow up 15 patients with resectablepancreatic cancer. Results Among these tumor markers, CA199 was the best diagnostic index; its sensitivity andspecificity were 74. 11% and 90%, respectively. The sensitivity of xombined assay was 89. 41%. After removingtumor, the levels of tumor markers were decreased to normal in 60% patients, and their reelevation indicated recurrence or metastasis. Conclusion These results suggest that combination assay of tumor markers is helpful toearly diagnosis of pancreatic cancer, and can also be used to evaluate treatment effect and to monitor tumor recurrence or metastasis.