结直肠癌干细胞对局部进展期直肠癌新辅助治疗影响的研究进展

局部进展期中低位直肠癌新辅助治疗已成为直肠癌综合治疗的重要组成部分;虽然近年来取得的治疗效果令人鼓舞,但不同的患者其治疗效果还存在较大差异。肿瘤干细胞概念的提出和对结直肠癌干细胞表型及功能特征、分子生物学机制及信号转导通路、周围微环境的研究进展,对局部进展期中低位直肠癌新辅助治疗中的个体化放疗、化疗提供了新的治疗思路和方法。

Research progress of colorectal cancer stem cells in the neoadjuvant therapy of locally advanced rectal cancer

Neoadjuvant therapy has been one of important therapeutic treatments for patients with locally advanced mid-low rectal cancer .Although much progress has been made with encouraging outcome , there were still some patients with poor prognosis .The concept of cancer stem cells has been proposed recently and the research progress have been made , including phenotype and functional characteristics of colorectal cancer stem cells , as well as molecular biological mechanism , signal transduction pathway and the surrounding microenvironment .This paper reviewed current research progress of such fields , and try to provides new ideas of individual radiotherapy and chemotherapy for patients with locally advanced mid -low rectal cancer .