肝癌行肝切除术后的血清GP73变化及与患者预后的关系

目的观察肝癌行肝切除术后的血清GP73变化及与患者预后的关系。方法以2013年3月至2014年3月接受肝切除术的80肝癌患者为观察对象,并根据其预后分为好转组(48例)和恶化组(32例)。采用SPSS11.5统计软件进行分析。两组患者GP73水平采用均数±标准差表示,不同临床特征的比较采用单因素方差分析或t检验;相关性分析采用Pearson相关分析法计算其相关系数(r)。P0.05为差异有统计学意义。结果恶化组患者术后血清中的GP73水平为(242.75±18.03)ng/ml,明显高于好转组(155.89±20.32)ng/ml,t=19.576,P0.05;分化程度低、肿瘤直径≥5 cm、有远处转移、乙型肝炎病毒(HBV)阳性、侵犯血管、侵犯淋巴和AFP≥400 ng/ml的肝癌患者术后血清GP73水平较高;肝切除术后GP73水平与AST、ALT等肝功能指标以及CA19-9、AFP等肿瘤标志物指标呈正相关,以上差异均有统计学意义。结论肝癌患者行肝切除术后病情恶化的患者血清GP73水平较高,且GP73水平受多种因素的影响,其与患者术后的肝功能和肿瘤标志物水平呈正相关。

Correlation of serum GP73 level and prognosis of patients with hepatocellular carcinoma after hepatectomy

Objective To observe the changes of serum GP 73 and to investigate its relationship with the prognosis of patients with hepatocellular carcinoma after hepatectomy . Methods 80 HCC patients who underwent hepatectomy in our hospital from March 2013 to March 2014 were divided into relief group (48 cases) and deterioration group ( 32 cases ) according to their prognosis . Statistical analysis were performed by using SPSS11.5 software.The level of serum GP73 expressed as mean ±standard deviation . Comparison of GP73 level in patients with different clinical features were examined by single factor variance analysis or t test.Pearson correlation analysis method was employed to calculate the correlation coefficient (r).A P value of <0.05 was considered as statistically significant difference . Results The serum level of GP73 in the patients of deterioration group was ( 242.75 ±18.03 ) ng/ml, which was higher than (155.89 ±20.32) ng/ml of the relief group, with significant difference, t =19.576, P <0.05.Data showed that high level of GP 73 could be observed in patients with poor differentiation tumor , with tumor diameter of≥5 cm, with distant metastasis, with HBV positive, with vascular or lymph invasion or AFP ≥400 ng/ml.The level of GP73 were positively correlated with AST , ALT as well as CA19-9, AFP, with statistically significant difference. Conclusion The level of serum GP73 in patients with poor prognosis after hepatectomy is increased , which could also be affected by multiple factors .Serum GP73 level is also positively correlated with the level of liver function and tumor markers .