p27在甲状腺滤泡状肿瘤中的表达及其意义

目的 了解p27在良恶性甲状腺滤泡状肿瘤中的表达及其意义。方法 应用S－P免疫组化法、测定了53例甲状腺滤状肿瘤及10例正常甲状腺组织中p27的表达。结果 p27蛋白表达水平在正常甲状腺组织最高，甲状腺滤泡状腺瘤次之，甲状腺滤泡状腺癌最低，其中甲状腺滤泡状腺癌微浸润型与广泛浸润型及转移型与非转移型比较，差异均无显著性意义（P＞0．05）。Logistic回归分析显示，p27能有效地判别甲状腺腺瘤与滤泡状腺癌（P=0.0048)。结论 p27参与了甲状腺滤泡状上皮的恶性转化，甲状腺滤泡状上皮的转化可能与p27蛋白降低有关,p27蛋白表达水平的测定有助于甲状腺滤泡状肿瘤良恶性的鉴别。

THE SIGNIFICANCE OF EXPRESSION OF P27 IN THYROID FOLLICULAR TUMORS

Objective To study the significance of expression of p27 in thyroid follicular tumors. Methods The tumor samples were obtained from 53 thyroid follicular tumors, and 10 normal thyroid tissues were used as a control group. p27 was detected by the immunohistochemical staining S P method. Results The normal thyroid group had the highest expression of p27.There were significant differences in the expression of p27 between thyroid follicular adenomas (FA) and follicular carcinomas (FTC), FA had much higher expression of p27 than FTC did. There were no significant differences in the p27 staining indexes between minimally and widely invasive FTC nor between metastized and non metastized FTC. Logistic regression showed that p27 were effective in distinguishing FA from FTC( P =0.0048). Conclusion It appears that p27 may be necessary for the malignant transformation of the thyroid follicular epithelium, which might relate to a decrease in p27. p27 detection may be helpful in distinguishing FA from FTC.