胰腺癌血清肿瘤标记物的表达及其临床意义

目的 观察胰腺癌患者血清肿瘤标记的表达，以寻找对胰腺癌诊断与随访有价值的血清肿瘤标记物。方法 采用免疫分析法和放射免疫法检测62例胰腺癌患者血清AFP、CEA、CA50、CA15-3、CA19-9、CA72-4和CA125共7种肿瘤标记物的表达，并取以胃肠道肿瘤患者和良性疾病患者各16例作为对照。结果 7种肿瘤标记物中，CA19-9、CA50和CA125对胰腺癌诊断的相对价值较高，尤以CA19-9的诊断价值最高，灵敏度和特异度分别为90.6%和86.7%，切除术后监测上述三项指标呈下降趋势，结论 血清CA19-9、CA50和CA125的检测对胰腺癌的诊断和随访是有价值的。

CLINICAL VALUE OF SERUM TUMOR MARKERS EXPRESSION IN DIAGNOSIS OF PANCREATIC CARCINOMA

Objective To search for valuable s erum tumor markers in diagnosis and prognosis of pancreatic carcinoma. Methods Seven kinds of serum tumor markers incl uding AFP,CEA,CA50, CA15-3,CA19-9,CA72-4 and CA125 were detected in 62 patien ts with pancreatic carcinoma by Auto DELFIA and IRMA, 16 patients with other gas trointestinal tumors and 16 patients with benign diseases served as control. And 19 patients after pancreatectomy were followed up. Results Among these 7 kinds of tumor markers, C A19-9,CA50 and CA125 were valuable in diagnosis of pancreatic carcinoma. CA19- 9 was the most valuable one, whose sensitivity and specificity were 90.6 % and 86.7% respectively. After resection of the tumor, the 3 markers tended to decrease significantly. Conclusion Serum CA19-9,CA50 and CA125 were v aluable in diagnosis and following up of pancreatic carcinoma.