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| 膀胱癌与P16基因缺失关系的探讨 | |
| 引用本文： | 李泽惠,许绍斌,郭萍,石勇刚,章宗籍,褚嘉档.膀胱癌与P16基因缺失关系的探讨[J].临床泌尿外科杂志,2000,15(6):271-272. |
| 作者姓名： | 李泽惠 许绍斌 郭萍 石勇刚 章宗籍 褚嘉档 |
| 作者单位： | 1. 昆明医学院附属第二医院泌尿外科,昆明,650101 2. 中国医学科学院医学生物研究所遗传室 3. 昆明医学院病理教研室 4. 昆明医学院附属第一医院泌尿外科 |
| 基金项目： | 云南省应用基础研究项目 |
| 摘 要： | 探讨膀胱癌的发生与Ｐ１６基因缺失的关系。方法：采用双重ＰＣＲ法对３１例膀胱癌组织中Ｐ１６基因进行检测。结果：３１例膀胱癌组织中有７例存在Ｐ１６基因缺失，缺失率为２２．６％。结论：Ｐ１６基因缺失与某些膀胱癌的发生存在一定的联系。 |
| 关 键 词： | 膀胱肿瘤 聚合酶链反应 基因缺失 P16基因 |
The deletions of P16 gene detected in bladder cancer by duplex PCR |
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| LI Ze-hui,XU Shao-bin,GUO Ping,SHI Yong-gang,ZHANG Zhong-ji,ZHU Jia-you.The deletions of P16 gene detected in bladder cancer by duplex PCR[J].Journal of Clinical Urology,2000,15(6):271-272. | |
| Authors: | LI Ze-hui XU Shao-bin GUO Ping SHI Yong-gang ZHANG Zhong-ji ZHU Jia-you |
| Abstract: | Purpose:To investigate the deletion of P16 g ene in the bladder cancer.Methods:The P16 gene was analysi s by duplex PCR in 31 bladder cancer tissue samples.Results:The gene deletions were found in seven samples.The deletion ratio of P16 gene was 22.6 per cent.Five cases had deletion in exon 2. One case had deletion in exon 1 and one had deletion in both exon 1 and exon 2.Conclusions:The results suggest that the deletion of P16 gene were associated with some bladder cancer. |
| Keywords: | Bladder tumor Gene P16 Polymeruse chain reaction Gene deletion |
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