p53及Ki-67在腺性膀胱炎中的表达及其临床意义

目的：检测腺性膀胱炎（CG）组织中p53及Ki-67的表达。方法：用免疫组化染色法观察56例CG、11例慢性膀胱炎（CC）、56例膀胱移行细胞癌（TCC）以及9例正常膀胱移行上皮中p53及Ki-67的表达。并进一步比较CG患者接受治疗前后膀胱组织中p53及Ki-67表达水平的变化。结果：肠化生型CG（CGIT）患者膀胱组织中p53及Ki-67的表达水平均显著高于典型型CG（CGTP）、Cc患者及正常对照组（P〈0．001）。CGIT与TCC组之间以及CGTP、CC及正常对照组之间差异无统计学意义（P〉0．05）。CGIT及TCC患者膀胱组织中p53与Ki-67的表达水平呈显著正相关（r=0．351，P=0．001）。治疗后CGTP、CGIT患者膀胱组织中p53及Ki-67的表达水平与治疗前相比均有明显下降（P〈0．001）。结论：CGIT存在恶变潜能。但手术及术后的化疗药物膀胱灌注治疗可以降低这种风险。

The p53 and Ki-67 Expression and its Clinical Significance in Patients with Cystitis Glandularis

Objective:To determine the p53 and Ki-67 expression and their clinical significance in tissue samples of patients with cystitis glandularis(CG).Methods:Tissues from 123 patients,including 56 cases of CG,11 cases of chronic cystitis(CC) and 56 cases of bladder transitional cell carcinoma(TCC) were selected and immunohisto-chemical staining for p53 and Ki-67 were performed.Another 9 specimens of normal bladder epithelial were also evaluated as control.And the changes of both p53 and Ki-67 expression before and after treatment were further studied.Results:The p53 and Ki-67 expression in intestinal type of CG(CGIT) were higher than that in typical type of CG(CGTP),CC and control groups(P <0.001).There were no significant differences in both p53 and Ki-67 expression between CGIT and TCC groups(P > 0.05).The results among CGTP,CC,control groups were similar(P > 0.05).The expression levels of p53 and Ki-67 in CG and TCC groups were positively correlated as(r =0.351,P =0.001).The p53 and Ki-67 expression levels were reduced significantly after treatment( P < 0.001).Conclusions;Although CGIT has the malignant potential,transurethral electronresection combined with intravesical instillation of chemotherapeutics can reduce this risk.