前列腺根治术前肥胖相关的生化指标对前列腺癌患者预后的意义

目的:探讨前列腺癌根治术(RP)前肥胖相关生化指标总胆汁酸、空腹血糖(FBG)、血尿酸、总胆固醇、甘油三酯、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)]预测前列腺癌患者预后的价值.方法:选取635例前列腺癌手术患者,根据指南分为低、中、高危三组,在RP前检测并收集其肥胖相关生化指标.根据各指标的正常值,将各组前列...

Prognostic significance of obesity-related biochemical indices in patients with prostate cancer before radical prostatectomy

Objective:To investigate the roles of pretreatment obesity-related biochemical markerstotal bile acid,fasting blood glucose(FBG),blood uric acid,total cholesterol,triglyceride,high-density lipoprotein(HDL),low-density lipoprotein(LDL)]in the prognosis of prostate cancer patients.Methods:Six hundred and thirty-five patients with prostate cancer which were treated by surgery were enrolled.According to the guidelines,patients were divided into three groups,low,medium and high risk.Obesity-related biochemical markers were determined and gathered before radical prostatectomy.According to the normal value of each marker,each group of prostate cancer patients were divided into high group and non-high group.Chi-square test was used for the intergroup difference among various indicators.Kaplan-Meier method was used for survival analysis,and Cox regression analysis was used to evaluate the prognostic value of each index in patients with prostate cancer of surgery.Results:Kaplan-Meier analysis showed that,whether it is 1-year overall survival rate(OS)or cancer specific survival rate(CSS),patients with high total bile acid,high FBG,high serum uric acid and high LDL have a significantly higher mortality than those patients in non-high group(P<0.05).Cox regression analysis showed that total bile acid and FBG were independent risk factors for OS and CSS in prostate cancer patients(P<0.05).However,Low HDL was only independent risk factor for CSS in prostate cancer patients.Furthermore,Triglyceride is not associated with prognosis in prostate cancer patients.Conculsion:Total bile acid and FBG can be used as independent indicators to predict the prognosis of patients undergoing radical prostatectomy.Patients with high total bile acid and high FBG have a poor prognosis after surgery.