| 132例男性不育患者遗传学病因分析 |
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| 引用本文： | 宋丹,钱卫平,许晓清,谭玉梅.132例男性不育患者遗传学病因分析[J].临床泌尿外科杂志,2004,19(9):543-544. |
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| 作者姓名： | 宋丹 钱卫平 许晓清 谭玉梅 |
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| 作者单位： | 深圳市罗湖医院生殖中心,广东,深圳,518001 |
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| 摘 要： | 目的：对男性不育患者进行遗传学病因分析，并探讨其遗传效应。方法：采取132例男性不育患者外周血进行染色体核型分析。结果：132例男性不育患者中，染色体异常24例，染色体变异22例。其中大Y20例，47，XXY18例，45．XY，t(13；14)3例，小Y和46，XY，inv(9)各2例，46，XY，t(9；22)1例。结论：染色体异常是男性不育的重要原因，并建议男性不育患者进行基因诊断，以便确诊是否属于遗传病，为生育提供指导，避免盲目治疗。
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| 关 键 词： | 男性不育 染色体异常 遗传效应 |
| 文章编号： | 1001-1420(2004)09-0543-02 |
| 修稿时间： | 2004年5月13日 |
Genetic analysis of 132 infertile men |
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| SONG Dan,QIAN Weiping,XU Xiaoqing,TAN Yumei.Genetic analysis of 132 infertile men[J].Journal of Clinical Urology,2004,19(9):543-544. |
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| Authors: | SONG Dan QIAN Weiping XU Xiaoqing TAN Yumei |
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| Institution: | SONG Dan 1 QIAN Weiping 1 XU Xiaoqing 1 TAN Yumei 1 |
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| Abstract: | Objective:To study the genetic effect on man infertility according to their karotypes.Method:Karyotypes of 132 infertile men were analyzed by chromosome G banding and C banding methods.Results:24 various abnormal karyotypes and 22 chromosome polymorphisms were found in 132 cases, including 20 case of Yqh+, 18 cases of Klinefelter's syndrome, 3 cases of 45, XY, t(13;14); 2 cases of Yqh- and 46, XY, inv(9) each, 1 case of 46, XY, t(9;22).Conclusions:Chromosomal abnormality is an important cause in male infertility. Gene diagnosis was advised to diagnose genetic disease or not, which offer guidance on reproduction and avoid blindness therapy. |
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| Keywords: | Male infertility Chromosome abnormality Genetic effect |
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