抗抑郁剂治疗手术后胃瘫综合征31例临床分析

目的：探讨精神、心理因素与手术后胃瘫综合征的关系及抗抑郁剂对其的疗效。方法：对31例正常人和31例手术后胃瘫综合征患者进行汉密尔顿抑郁量表（HAMD）、汉密尔顿焦虑量表（HAMA）和症状自评量表（SCL-90）评分;31例手术后胃瘫综合征患者用5-羟色胺再摄取抑制剂（SSRI）西酞普兰治疗,疗程均为8周,治疗后再行量表评分。结果：3种量表（HAMD、HAMA、SCL-90）评分结果,均显示手术后胃瘫综合征患者的精神、躯体症状与正常人之间差异有非常显著性（P〈0.01）;手术后胃瘫综合征患者接受抗抑郁剂治疗8周后,精神和躯体症状均有明显改善。结论：手术后胃瘫综合征与精神心理因素相关,患者普遍存在抑郁和焦虑情绪,用抗抑郁剂治疗能显著改善精神和躯体两方面症状。

Clinical analysis of postsurgical gastroparesis syndrome treated with antidepressant: a report of 31 cases

Objective:To investigate the role of psychological factors in postsurgical gastroparesis syndrome,and the effect of antidepressant treatment.Methods:Thirty-one patients with postsurgical gastroparesis syndrome were treated with antidepressants(citalopram)for 8 weeks.Before and after 8-week treatment,the psychological status of the patients were analyzed by Hamilton Depression(HAMD),Hamilton Anxiety(HAMA)and SCL-90 scales,and compared to those of 31 health volunteers.Results:There were significant difference in somatic and psychological scores in HAMD,HAMA and SCL-90 scores between the two groups(P<0.01).The scores of pa- tients were significantly improved after 8 weeks of treatment(P<0.01).Conclusion:Psychological factors play a role in postsurgical gastroparesis syndrome.Antidepressants are effective in the treatment of disorder of psycho logical as well as physical function.