首页 | 本学科首页   官方微博 | 高级检索  
检索        

肾移植术后并发恶性肿瘤的临床研究
引用本文:田野,张玉海,解泽林,马麟麟,唐雅望,孙雯,郭宏波.肾移植术后并发恶性肿瘤的临床研究[J].中华器官移植杂志,1998,19(3):169-171.
作者姓名:田野  张玉海  解泽林  马麟麟  唐雅望  孙雯  郭宏波
作者单位:首都医科大学附属北京友谊医院泌尿科,100050
摘    要:1985~1996年共行同种异体肾移植术1211例,均采用环孢素A、硫唑嘌呤及泼尼松三联免疫抑制治疗。术后发生恶性肿瘤15例,发生率为1.2%。肿瘤发生的部位包括:皮肤、口腔、食道、胃、肺、肝以及泌尿系统,其中泌尿系统恶性肿瘤占9例。移植术后至肿瘤诊断的时间平均为29.2个月。治疗措施为减少环孢素A的用量及肿瘤切除。8例患者发生肿瘤转移,并在1年内死于肿瘤晚期。认为肾移植术后恶性肿瘤的发生及种类因种族和地域的差异而有所不同,在治疗上困难较大,可减少环孢素A的用量至原用量的1/4,如病情不能控制,应以抢救生命为主。

关 键 词:肾移植  肿瘤  术后并发症

Clinical study on the development of malignancy in renal allograft recipients
%.Clinical study on the development of malignancy in renal allograft recipients[J].Chinese Journal of Organ Transplantation,1998,19(3):169-171.
Authors:%
Abstract:From 1985 to 1996, 1 211 cadaveric kidney transplantation were performed in our hospital. All recipients were treated by CsA+Aza+Pred triple immunosuppressive therapy. Fifteen cases of malignancy (9 males and 6 females) were detected with the overall incidence being 1.2%. The involved organs or tissues included skin, mouth, esophagus, stomach, lung, liver,and urological system (9 patients). The average appearance time of the tumors in the 15 recipients after transplantation was 29.2 (3/84) months. Eight patients with metastasis died within one year of diagnosis. The etiology, clinical features and treatment of the malignancy following renal transplantation were discussed. The development and kinds of malignancy following renal transplantation were different because of the difference of races and regions. The treatment included the decrease of CsA dosage to 1/4 of its original dosage and the complete removal of the tumor lesion.
Keywords:Kidney/transplantation  Immunosuppression  Neoplasms  
本文献已被 CNKI 维普 万方数据 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号