| 睾丸间质细胞凋亡及调控 |
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| 引用本文： | 袁双虎,徐斯凡.睾丸间质细胞凋亡及调控[J].中华男科学杂志,2003,9(3):218-220,225. |
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| 作者姓名： | 袁双虎 徐斯凡 |
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| 作者单位： | 江西医学院生理学教研室,江西,南昌,330006 |
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| 摘 要： | 睾丸间质细胞 (Leydigcells,LC)的发生与成熟过程都和细胞凋亡相关 ,一定范围内的凋亡对机体具有积极的生理意义 ,但过度凋亡会使睾酮 (T)分泌明显减少 ,导致生精细胞凋亡增加 ,甚至不育。二甲磺基乙烷 (ethanedimethane sulphonate,EDS) ,糖皮质激素 ,下丘脑 垂体 睾丸轴分泌的促性腺激素释放激素 (GnRH)、卵泡刺激素 (FSH)、黄体生成素 (LH) /绒毛膜促性腺激素 (hCG)、T等激素 ,LC发育阶段及其他一些因素都会影响其凋亡。多个基因参与LC凋亡的调控 ,SCF/c kit、Bcl 2、Bcl xl可抑制其凋亡 ,caspase 3、Fas、Bax和clusterin可促进其凋亡
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| 关 键 词： | 睾丸 间质细胞 细胞凋亡 调控 |
| 文章编号： | 1009-3591(2003)03-0218-04 |
Leydig Cell Apoptosis and Its Regulation |
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| Shuang-Hu YUAN,Si-Fan XU.Leydig Cell Apoptosis and Its Regulation[J].National Journal of Andrology,2003,9(3):218-220,225. |
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| Authors: | Shuang-Hu YUAN Si-Fan XU |
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| Institution: | Department of Physiology, Jiangxi Medical College, Nanchang, Jiangxi 330006, China. yuanshuanghu@sina.com |
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| Abstract: | Apoptosis is necessary for the development and maturation of Leydig cells. However, increased apoptosis results the decline of testosterone production, which may increase germ cell apoptosis and the possibility of infertility. There are several aspects contributing to Leydig cell apoptosis such as ethane dimethanesulphonate (EDS), glucocorticoid, developmental stage and some hormones including FSH, LH/hCG and testosterone. A number of genes are involved in the regulation of Leydig cells apoptosis. It was reported that SCF/c-kit, Bcl-2 and Bcl-xl inhibited the apoptosis while caspase-3, Fas, Bax and clusterin stimulated it. Natl J Androl,2003,9(3):218-220,225 |
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| Keywords: | Testis Leydig cell Apoptosis Regulation |
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