| 无精子症和严重少精子症DYS240基因位点的分析 |
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| 引用本文： | 沙家豪,周作民,王黎熔,林敏,周亚东,朱虎.无精子症和严重少精子症DYS240基因位点的分析[J].中华男科学杂志,1997(1). |
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| 作者姓名： | 沙家豪 周作民 王黎熔 林敏 周亚东 朱虎 |
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| 作者单位： | 南京医科大学组胚教研室!南京，210029 |
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| 摘 要： | 无精子因子（AZF）的缺失将导致无精子症和严重少精子症。本研究应用PCR方法分析了65倒核型正常的无精子症和25例核型正常的严重少精子症病人的DYS240基因位点。结果显示，无精子症病人中6例缺失DYS240基因位点，严重少精子症病人中4例缺失DYS240基因位点。提示DYS240基因是AZF的一个重要的候选成分。
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| 关 键 词： | AZF DYS240 PCR |
Analysis of DYS240 locus in azoospermic and oligospermic men |
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| Sha Jiahao,Zhou Zuomin, Wang Lirong et al.Analysis of DYS240 locus in azoospermic and oligospermic men[J].National Journal of Andrology,1997(1). |
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| Authors: | Sha Jiahao Zhou Zuomin Wang Lirong |
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| Abstract: | It has been proved that the deletion of azoospermia factor (AZF) could cause azoospermia or severe oligospermia. In this paper, DYS240 locus were analysed in 65 azoospermic men and 25 oligospermic men with a cytologically normal Y chromosome by using PCR. DYS240 deletion were found in 6 azoospermic men and 4 in oligospermic men. The results suggested that DYS240 locus is one of the important candidates for AZF. |
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| Keywords: | AZF DYS240 PCR |
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