| 前列腺癌中内皮素及其受体的研究进展 |
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| 引用本文： | 王青兵,渠武帅,秦大山,王志平.前列腺癌中内皮素及其受体的研究进展[J].中华男科学杂志,2006,12(5):450-452. |
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| 作者姓名： | 王青兵 渠武帅 秦大山 王志平 |
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| 作者单位： | 兰州大学第二医院泌尿外科,甘肃,兰州,730030 |
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| 摘 要： | 内皮素是一种主要由血管内皮细胞产生的肽类物质,不仅具有强大的血管收缩功能,而且还有一些重要的生理学作用,如组织分化、细胞增殖及激素分泌等。近年来的研究发现内皮素还参与体内多种肿瘤的生长过程,如前列腺癌、宫颈癌、乳腺癌等,其生物学效应的实现可能与促有丝分裂、抑制凋亡、诱导肿瘤生长过程中的血管生成、原癌基因的激活等有关。晚期前列腺癌患者骨转移、成骨作用及疼痛等均与其有关。
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| 关 键 词： | 前列腺癌 内皮素1 受体 |
| 文章编号： | 1009-3591（2006）05-0450-03 |
| 收稿时间： | 2005-05-10 |
| 修稿时间： | 2005-09-20 |
Roles of Endothelin and Its Receptors in Prostate Cancer |
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| WANG Qing-bing,QU Wu-shuai,QIN Da-shan,WANG Zhi-ping.Roles of Endothelin and Its Receptors in Prostate Cancer[J].National Journal of Andrology,2006,12(5):450-452. |
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| Authors: | WANG Qing-bing QU Wu-shuai QIN Da-shan WANG Zhi-ping |
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| Institution: | Department of Urology, the Second Hospital of Lanzhou University, Lanzhou, Gansu 730030, China |
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| Abstract: | Endothelin(ET) is a peptide released by vascular endothelial cells.Except for the potent vasoconstrictor function it plays an important physiological role in tissue differentiation and development,cell proliferation and hormone production.Investigation of the role of ET axis in a variety of tumors such as prostatic,cervical,breast carcinoma has provided evidences of its importance in cancer,recently.Data suggest that multiple functions of the ET axis have associations with mitogenesis,apoptosis inhibition,angiogenesis,and activation of proto-oncogene.The ET axis relates to invasiveness,osteoblast function,and metastatic cancer pain in advanced prostate cancer. |
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| Keywords: | prostate cancer endothelin-1 receptor |
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