首页 | 本学科首页   官方微博 | 高级检索  
检索        

左旋肉碱和乙酰左旋肉碱合用治疗少弱精子症有效性与安全性的多中心随机对照临床研究
引用本文:李铮,陈国武,商学军,白文俊,韩银发,陈斌,滕晓明,孟凡会,张滨,陈德宁,刘继红,郑新民,曹小蓉,刘勇,朱晓斌,王益鑫.左旋肉碱和乙酰左旋肉碱合用治疗少弱精子症有效性与安全性的多中心随机对照临床研究[J].中华男科学杂志,2005,11(10):761-764.
作者姓名:李铮  陈国武  商学军  白文俊  韩银发  陈斌  滕晓明  孟凡会  张滨  陈德宁  刘继红  郑新民  曹小蓉  刘勇  朱晓斌  王益鑫
作者单位:上海第二医科大学附属仁济医院泌尿外科 上海200001 (李铮,韩银发,陈斌,曹小蓉,刘勇,朱晓斌),上海集爱遗传与不育诊疗中心 上海200011 (陈国武),南京军区南京总医院男科 江苏南京210002 (商学军),北京大学人民医院男科 北京100044 (白文俊),上海第一妇婴保健院男科 上海200040 (滕晓明),青岛大学医学院附属医院生殖医学中心 山东青岛266003 (孟凡会),广州中山大学附属第三医院性医学与不育科 广东广州510630 (张滨),深圳市中医院男科 广东深圳518033 (陈德宁),华中科技大学同济医学院附属同济医院泌尿外科 湖北武汉430030 (刘继红),武汉大学中南医院泌尿外科 湖北武汉430071 (郑新民),上海第二医科大学附属仁济医院泌尿外科 上海200001(王益鑫)
摘    要:目的:探讨左旋肉碱和乙酰左旋肉碱合用治疗少弱精子症的安全性与有效性。方法:150例特发性少弱精子症患者入选本研究,按3∶2的比例随机分为治疗组与对照组。治疗组90例每次服用左旋肉碱1.0 g与乙酰左旋肉碱0.5 g,早晚各1次。对照组60例服用维生素E 100 mg和维生素C 100 mg,3次/d。每30 d为1个疗程,连续治疗3个疗程。高效液相色谱法检测精浆中左旋肉碱治疗前后的变化,每月复查精液,观察服药后的不良反应与女方妊娠情况。结果:治疗3个月后,治疗组90例中85例完成本研究,女方临床妊娠10(11.6%)例;治疗前后每次射精中前向运动精子总数、运动精子总数、左旋肉碱浓度和总量有显著增加,其差别有统计学意义(P<0.01)。对照组60例中完成3个月治疗的53例,女方妊娠2例(3.7%);治疗前后每次射精中前向运动精子总数、运动精子总数、左旋肉碱浓度和总量虽有改变(P>0.05)。两组临床妊娠率差异显著(P<0.05),未见明显不良反应。结论:左旋肉碱和乙酰左旋肉碱合用治疗少弱精子症,可显著提高每次射精中前向运动精子和运动精子总数,提高女方临床妊娠率,安全有效。

关 键 词:男性不育  左旋肉碱  乙酰左旋肉碱  对照研究
文章编号:1009-3591(2005)10-0761-04
收稿时间:2005-08-20
修稿时间:2005-09-20

A Controlled Randomized Trial of the Use of Combined L-carnitine and Acetyl-L-carnitine Treatment in Men with Oligoasthenozoospermia
LI Zheng, CHEN Guo-wu, SHANG Xue-jun, BAI Wen-jun, HAN Yin-fa, CHEN Bin, TENG Xiao-ming, MENG Fan-hui, ZHANG Bin , CHEN De-ning, LIU Ji-hong, ZHENG Xin-min, CAO Xiao-rong , LIU Yong, ZHU Xiao-bin, WANG Yi-xin.A Controlled Randomized Trial of the Use of Combined L-carnitine and Acetyl-L-carnitine Treatment in Men with Oligoasthenozoospermia[J].National Journal of Andrology,2005,11(10):761-764.
Authors:LI Zheng  CHEN Guo-wu  SHANG Xue-jun  BAI Wen-jun  HAN Yin-fa  CHEN Bin  TENG Xiao-ming  MENG Fan-hui  ZHANG Bin  CHEN De-ning  LIU Ji-hong  ZHENG Xin-min  CAO Xiao-rong  LIU Yong  ZHU Xiao-bin  WANG Yi-xin
Institution:Department of Urology, Renji Hospital of Shanghai Second Medical Univesity, Shanghai 200001, China. lizhengboshi@163.com
Abstract:Objective: To determine the efficacy and safety of combined L-carnitine and acetyl-L-carnitine therapy in infertile males with oligoasthenozoospermia.Methods: One hundred fifty patients with oligoasthenozoospermia were randomized selected into treatment and control groups.The treatment group with 90 patients were given L-carnitine(2 g/d) and acetyl-L-carnitine((1) g/d) orally,twice a day.The patients in control group were given Vitamin E 100 mg plus Vitamin C 100 mg,tid.The oral therapy lasted three months and patients accepted sperm analysis every one month.The L-carnitine level in seminal plasma was examined by high performance liquid chromatography(HPC).Side effects as well as pregnant rate were observed. Results: In the treatment group,85 patients out of 90 finished the three month treatment.Female spouses of 10 patients((11.6)%) achieved pregnancy.Moreover,their forward motile sperm per ejaculation,total motile sperm,as well as the concentration of L-carnitine in seminal plasma were increased significantly(P<(0.01)).In control group,53 patients out of 60 completed three months therapy.Two pregnancy((3.7)%) was observed.Though some increase was seen in number of forward motile sperm and total motile sperm per ejaculation,the changes were not statistically significant(P>(0.05)).The difference of the pregnant rate between two groups was statistically significant.No side effects were found.Conclusion: Combined treatment with L-carnitine and acetyl-L-carnitine can be an effective and safe option for treating oligoasthenozoospermia by means of significantly improving forward motile sperm and total motile sperm per ejaculation,as well as increasing pregnant rates. Natl J Androl,2005,11(10):761-764
Keywords:L-carnitine  acetyl-L-carnitine  male infertility  oligoasthenozoospermia  compared research
本文献已被 CNKI 维普 万方数据 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号