MRI 3D-LAVA动态增强联合FRFSE序列诊断早期前列腺癌的效能

目的探讨核磁共振成像（MRI）三维容积内插快速扰相梯度回波序列（3D-LAVA）屏气检查动态增强联合快速翻转快速自旋回波序列（FRFSE）对早期前列腺癌的诊断效能。 方法对我院2013年6月至2019年6月210例可疑早期前列腺癌的临床资料进行回顾，均实施MRI 3D-LAVA动态增强、FRFSE序列扫描。总结两种扫描序列的检查结果，分析不同方法诊断早期前列腺癌的效能；另统计多参数磁共振（mpMRI）的诊断结果，绘制受试者工作特征曲线（ROC）评价不同方法诊断早期前列腺癌的效能。 结果早期前列腺癌的构成比为38.10%；早期前列腺癌（+）患者峰值和强化率均高于前列腺癌（-）受检者，且早期前列腺癌（+）患者峰值时间短于后者，强化幅度小于后者，差异均有统计学意义（P<0.05）；MRI 3D-LAVA动态增强联合FRFSE序列诊断早期前列腺癌的灵敏度与MRI 3D-LAVA动态增强、FRFSE序列单独诊断相近，特异度、准确度和曲线下面积（AUC）均高于单独诊断；MRI 3D-LAVA动态增强联合FRFSE序列诊断早期前列腺癌的灵敏度、特异度、准确度均与mpMRI相当，且二者AUC对比差异无统计学意义（P>0.05）。 结论在早期前列腺癌诊断中MRI 3D-LAVA动态增强、FRFSE序列扫描联合检查的效能理想，与病理结果的一致性良好，和mpMRI诊断早期前列腺癌的效能相近。

Diagnosis of early prostate cancer by MRI of 3D-LAVA dynamic enhancement combined with FRFSE sequence

ObjectiveTo explore the diagnostic efficacy of three-dimensional MRI GRE sequence (3D-LAVA) gas-screen examination and fast recovery fast spin echo sequence (FRFSE) in early prostate cancer by magnetic resonance imaging (MRI). MethodsThe clinical data of 210 suspected cases of early prostate cancer in our hospital from June 2013 to June 2019 were reviewed. MRI 3D-LAVA and FRFSE sequence scanning were performed in all cases. The results of two scanning sequences were summarized and the efficacy of different methods in the diagnosis of early prostate cancer was analyzed. In addition, the diagnosis results of multi-parameter magnetic resonance imaging (mpMRI) were compared, and the receiver operating characteristic curve (ROC) was drawn to evaluate the efficacy of different methods in the diagnosis of early prostate cancer. ResultsThe ratio of early prostate cancer was 38.10%. The peak value and enhancement rate of early prostate cancer (+) patients were higher than those of prostate cancer (-) patients, and the peak time of early prostate cancer (+) patients was shorter than that of the latter, and the enhancement extent was smaller than that of the latter, the difference was statistically significant (P<0.05). The sensitivity of MRI 3D-LAVA dynamic enhancement combined with FRFSE sequence in the diagnosis of early prostate cancer was similar of MRI 3D-LAVA dynamic enhancement and FRFSE sequence alone, and the specificity, accuracy and AUC were higher than those of single diagnosis. The sensitivity, specificity and accuracy of 3D-LAVA dynamic contrast-enhanced MRI combined with FRFSE sequence in the diagnosis of early prostate cancer were comparable of mpMRI, and there was no significant difference in AUC between the two groups (P>0.05). ConclusionIn the diagnosis of early prostate cancer, the efficiency of combination of 3D-LAVA dynamic enhancement and FRFSE sequence scanning is effective, which is in good agreement with pathological results, and is similar of mpMRI in the diagnosis of early prostate cancer.