| 异种脱蛋白骨管移植修复大段骨缺损的力学评估 |
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| 引用本文： | 丁真奇,石玲玲,康两期,陈昱.异种脱蛋白骨管移植修复大段骨缺损的力学评估[J].临床骨科杂志,2010,13(2):200-203. |
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| 作者姓名： | 丁真奇 石玲玲 康两期 陈昱 |
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| 作者单位： | 解放军第175医院(厦门大学附属东南医院)全军创伤骨科中心,福建,漳州,363000 |
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| 基金项目： | 福建省自然科学基金计划资助项目(编号:2007J0300) |
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| 摘 要： | 目的研究异种脱蛋白骨管移植修复大段骨缺损的生物力学变化。方法建立山羊双侧胫骨大段骨缺损模型,36只山羊(72只后肢)随机分为2组,实验组:异种脱蛋白骨管;对照组:异种脱蛋白骨粒;两组均在移植骨中添加了骨形态发生蛋白(BMP),并采用骨板、钢板双重固定修复骨缺损。术后5、10、15周对羊胫骨行影像学观察和生物力学的变化。结果影像学显示实验组在骨缺损修复及成骨方面较对照组高。生物力学测试结果表明,术后5、10、15周时实验组力学强度较对照组明显增高,差异有统计学意义(P<0.05);术后15周,实验组的生物力学强度与正常胫骨已无差异。结论应用异种脱蛋白骨管支撑复合BMP修复大段骨缺损,能够有效加强移植骨修复负重骨缺损区的力学结构。
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| 关 键 词： | 异种骨 骨缺损 生物力学 骨形态发生蛋白质类 |
Biomechanical study of repairing the large segemental bone defect with deproteinized xenograft bone pipe as support frame |
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| DING Zhen-qi,SHI Ling-ling,KANG Liang-qi,CHEN Yu.Biomechanical study of repairing the large segemental bone defect with deproteinized xenograft bone pipe as support frame[J].Journal of Clinical Orthopaedics,2010,13(2):200-203. |
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| Authors: | DING Zhen-qi SHI Ling-ling KANG Liang-qi CHEN Yu |
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| Institution: | Orthopaedic Trauma Center of PLA/a>;the 175th Hospital of PLA/a>;Southest Hospital Affiliated to Xiamen University/a>;Zhangzhou/a>;Fujian 363000/a>;China |
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| Abstract: | Objective To study the biomechanical changes of the treatment of the large segmental bone defect by implanting deproteinized xenograft bone pipe.Methods The large segmental bone defects of bilateral tibia at adult goats were made.36 goats(72 tibiae) were randomly divided into two groups.The bone defects were repaired with deproteinized xenograft bone pipe in experimental group and deproteined xenograft bone particle in control group.Both of them were combined with bone morphogenetic protein(BMP) and treated... |
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| Keywords: | xenograft bone bone defect biomechanics bone morphogenetic proteins |
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