甘露醇预防血液透析相关低血压临床研究 |
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引用本文: | 车文体,邹贵勉,郭骏军,眭维国,邹和群.甘露醇预防血液透析相关低血压临床研究[J].临床肾脏病杂志,2010(3):115-117. |
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作者姓名: | 车文体 邹贵勉 郭骏军 眭维国 邹和群 |
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作者单位: | [1]中国人民解放军第181中心医院全军肾移植与透析治疗中心,桂林524001 [2]南方医科大学附属第三医院肾内科,桂林524001 |
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摘 要: | 目的探讨甘露醇注射液预防血液透析相关性低血压的适应症、使用方法和临床效果。方法选择血液透析中经常发生低血容量性低血压的患者40例,随机分为研究组与对照组,每组20例。研究组透析1h后静滴甘露醇150ml,对照组同一时间开始给予0.9%氯化钠注射液150ml,透析最后1h之前停止使用两种药物。结果研究组透析中低血压发生率(7%)显著低于对照组(48%),同时透析间期急性左心衰竭发生率(5%)也显著低于对照组(30%)。结论甘露醇注射液能降低血液透析相关性低血压的发生率,更容易达到目标超滤量,并因此减少透析间期急性左心衰竭的发生率。
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关 键 词: | 甘露醇 肾透析 低血压 治疗 |
Prevention of dialysis-associated hypotension with mannitol |
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Institution: | CHE Wen-ti , ZOU Gui mian , GUO Jun- jun ,et al.( Department of Nephrology No. 181st Hospital of PLA ,Guilin 541002,China) |
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Abstract: | Objective To explore the indication, application and clinical effect of mannitol in preventing dialysis-associated hypotension. Methods Forty hypotension-prone patients on maintenance hemodialysis were randomly divided into study group and control group(n = 20 in each group). The patients in the study group were intravenously injected with 20% mannitol( 150 ml) 1 h after the start of dialysis,and those in control group were administrated 0. 9% normal sodium(151) ml) at the same time. The treatments were withdrawn l h before the end of dialysis. Results The incidence of hypotension during hemodialysis(7%)in study group was significantly lower than that(48%)in control group. Meanwhile the incidence of interdialytic acute congestive heart failure in study group(5 % )was significantly lower than that(30%)in control group. Conclusions Intravenous drip of mannitol can effectively prevent dialysis-associated hypotension and easily achieve goal uhrafihration volume in hemodialysis, and reduce the incidence of acute congestive heart failure during dialysis. |
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Keywords: | Mannitol Renal dialysis Hypotension Therapy |
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