异种巩膜作为HA眼台包裹材料的实验研究

目的：观察猪巩膜作为羟基磷灰石（hydroxy apatite,HA)眼台包裹材料，应用于兔眼的临床表现及病理组织学改变。方法：对纯种新西兰大白兔行眼球摘除术后于肌锥内植入直径10mm HA眼台，并在其上覆盖边长10mm以上的正方形猪巩膜1块。4周后全麻下观察外眼，有无感染及有无上台暴露，取出上台并猪巩膜后，光镜下观察包裹材料与眼台的炎症反应情况及血管化情况。结果：10只兔中无一只眼台暴露或排出。经组织学观察可见猪巩膜的弹力纤维仍然排列紧密，部分有轻度肿胀，HA眼台中心有新生小血管长入，结论：异种（猪）巩膜作为HA眼台的包裹材料，应用于兔眼在临床表现上类似于同种异体巩膜，有望成为HA眼台包裹材料的新来源。

Experimental study of using xenologous sclera as wrapping materials for hydroxy apatite (HA)

Objective Use xenologous sclera (pig sclera) as wrapping materials for hydroxyapatite (HA) ocular implants in enucleated New Zealand white rabbits. Methods Ten rabbits were unilaterally enucleated and the sockets implanted with 10 mm HA spherical implants. All implants were wrapped with pig sclera. The rabbits were killed 4 weeks later and the sockets were examined clinically for inflammation and implant exposure. Exenterated specimens were assessed histopathologically for inflammation and vascularization. Results No clinical evidence of implant exposure or extrusion was detected in rabbits receiving pig sclera wrapped implants. Histopathologically the xenologous (pig) sclera displayed moderate inflammation, as well as maintain its lamellar arrangement without disruption. Fibrovascular ingrowth was complete in all implants. Conclusion Xenologous (pig) sclera behaves similar cliniclally to homologous sclera as a wrapping material for spherical HA ocular implants in a rabbit model, and may represent a reasonable alternative to sclera in such procedures in humans.;