| BMSCs构建组织工程软骨的研究进展 |
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| 引用本文： | 许澍洽,许扬滨.BMSCs构建组织工程软骨的研究进展[J].中国修复重建外科杂志,2008,22(2):163-166. |
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| 作者姓名： | 许澍洽 许扬滨 |
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| 作者单位： | 中山大学附属第一医院整形外科,广州,510080 |
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| 摘 要： | 目的综述BMSCs构建组织工程软骨的进展。方法查阅近10年来有关BMSCs构建组织工程软骨的文献，并进行综述。结果支架为软骨细胞的生长提供了理想的环境，细胞因子和基因修饰可促进BMSCs分化为软骨细胞，三者在软骨组织工程中具有重要作用。结论三维支架的改良、合理使用细胞因子及基因修饰技术的提高，将推动临床上软骨重建技术的发展。
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| 关 键 词： | 组织工程软骨 BMSCs 基因修饰 细胞因子 软骨组织工程 研究进展 CARTILAGE TISSUE CELL SEEDING ACTING PROGRESS 发展 重建技术 临床 修饰技术 基因修饰 使用 改良 三维支架 作用 细胞因子 环境 生长 |
| 收稿时间： | 2007-06-28 |
| 修稿时间： | 2007-07-31 |
RECENT PROGRESS OF BMSCs ACTING AS SEEDING CELL FOR TISSUE ENGINEERED CARTILAGE |
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| XU Shuqia,XU Yangbin.RECENT PROGRESS OF BMSCs ACTING AS SEEDING CELL FOR TISSUE ENGINEERED CARTILAGE[J].Chinese Journal of Reparative and Reconstructive Surgery,2008,22(2):163-166. |
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| Authors: | XU Shuqia XU Yangbin |
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| Institution: | Department of Plastic Surgery, First Affiliated Hospital, Sun Yat-sen University, Guangzhou Guangdong, 510080, P.R. China. |
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| Abstract: | Objective To review the recent progress of BMSCs acting as seeding cell for tissue engineered cartilage. Methods The recent ten years literature about BMSCs acting as seeding cell for tissue engineered cartilage was extensively reviewed. Results Scaffold provided an optimal environment for the growth of BMSCs. Cytokine and gene delivery could promote BMSCs to differentiate toward chondrocytes. All of them played important roles in the field of cartilage tissue engineering. Conclusion The improvement of three-dimensional scaffolds, the rational use of cytokine, and the enhancement of gene delivery will promote the development of clinical cartilage reconstruction. |
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| Keywords: | Tissue engineered cartilage BMSCs Gene delivery Cytokine |
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