急性肾盂肾炎应用左氧氟沙星的临床干预效果分析

目的：观察急性肾盂肾炎应用左氧氟沙星的临床干预效果。方法将我院2010年4月~2013年11月确诊并收治的110例急性肾盂肾炎患者随机分为临床组和参照组各55例。临床组应用左氧氟沙星静脉滴注进而口服治疗，参照组应用氨苄青霉素静脉滴注治疗进而用磺胺甲恶唑口服治疗。比照两组症状体征消失时间、临床疗效及治疗时间。结果两组用药完成后，症状体征逐渐改善，临床组其症状体征消失速度均显著好于参照组，差异有统计学意义（P＜0.05）。临床组总有效率为98.18%，参照组为96.36%，两组比较差异无统计学意义（P＞0.05）。但临床组其平均治疗时长显著低于参照组，差异有统计学意义（P＜0.05）。临床组1例发生恶心、呕吐，1例头晕，1例皮肤瘙痒；参照组4例发生恶心、呕吐。两组相比不良反应率差异无统计学意义（P＞0.05）。结论急性肾盂肾炎应用左氧氟沙星疗效确切，迅速缓解症状体征、疗程短、安全性好。

Analysis of clinical intervention effects of levofloxacin on acute pyelonephritis

ObjectiveTo investigate the clinical intervention effects of levofloxacin on acute pyelonephritis. Methods110 patients with acute pyelonephritis who were treated in our hospital from April 2010 to November 2013 were randomly divided into the clinical group and the reference group, with 55 patients in each group. The clinical group received intravenous drip of levofloxacin and then oral administration; The reference group received intravenous drip of penbritin and then oral administration of sulfamethoxazole. The symptom and sign disappearance time, clinical efficacy and treatment time of the two groups were compared.ResultsAfter the end of medication, the symptoms and sings improved gradually. The clinical group was significantly better than the reference group in both symptom and sign disappearance time, with statistically significant differences （P〈0.05）. The total effective rate of the clinical group was 98.18% and that of the reference group was 96.36%, with no statistically significant difference between the two groups （P〉0.05）. But the clinical group had significantly shorter average treatment duration than the reference group （P〈0.05）, with statistically significant difference. In the clinical group, 1 patient had nausea and vomiting, 1 patient had dizziness, and 1 patient had skin itch; In the reference group, 4 patients had nausea and vomiting. The two groups were not significantly different in the incidence of adverse reactions （P〉0.05）. ConclusionIn the treatment of acute pyelonephritis, the application of levofloxacin shows accurate efficacy, relieves symptoms and signs rapidly, and has short treatment course and good safety.