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Immunoglobulin deposits in liver tissue from infants with biliary atresia and the correlation to cytomegalovirus infection |
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| Authors: | Fischler Björn Woxenius Susanne Nemeth Antal Papadogiannakis Nikos |
| Institution: | a Department of Pediatrics, Huddinge University Hospital, Karolinska Institutet, SE-141 86 Stockholm, Sweden b Department of Immunology, Microbiology, Pathology, and Infectious Diseases, Huddinge University Hospital, Karolinska Institutet, SE-141 86 Stockholm, Sweden c Department of Biosciences at Novum, Huddinge University Hospital, Karolinska Institutet, SE-141 86 Stockholm, Sweden d Department of Pathology, Huddinge University Hospital, Karolinska Institutet, SE-141 86 Stockholm, Sweden |
| Abstract: | PurposeThe aim of this report was to study the amount and distribution of immunoglobulin deposits in liver biopsies from infants with biliary atresia (BA) and correlate the results to the cytomegalovirus (CMV) infection status.MethodsStored liver biopsies from 18 patients with BA and from 6 control patients without liver disease were immunohistochemically stained to detect IgG and IgM deposits. The intensity of the immunoglobulin staining was evaluated by a semiquantitative scoring scale. Ongoing CMV infection was defined as the detection of CMV-IgM in serum and/or the isolation of CMV in the urine and was noted in 9 of the patients with BA.ResultsWhen analyzing the immunoglobulin deposits on the hepatocellular canalicular membrane the intensity score for IgM deposits was significantly higher in biopsies from patients with BA infected with CMV than in those without. No canalicular staining was detected in control biopsies.ConclusionsThe results support the possibility that immunologic mechanisms are of importance in the pathogenesis of BA and that a CMV infection may trigger such mechanisms. |
| Keywords: | Biliary atresia Cytomegalovirus Etiology Immunoglobulin deposits |
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