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Metformin accelerates wound healing by Akt phosphorylation of gingival fibroblasts in insulin-resistant prediabetes mice
Authors:Hiromi Kominato  Kohei Takeda  Koji Mizutani  Risako Mikami  Daisuke Kido  Prima Buranasin  Natsumi Saito  Shu Takemura  Keita Nakagawa  Toshiyuki Nagasawa  Takanori Iwata
Institution:1. Department of Periodontology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Bunkyo-ku, Tokyo, Japan

Hiromi Kominato and Kohei Takeda contributed equally to this study.;2. Department of Periodontology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Bunkyo-ku, Tokyo, Japan;3. Oral Diagnosis and General Dentistry, Dental Hospital, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan;4. Department of Conservative Dentistry and Prosthodontics, Faculty of Dentistry, Srinakharinwirot University, Bangkok, Thailand;5. Division of Advanced Clinical Education, Department of Integrated Dental Education, School of Dentistry, Health Sciences University of Hokkaido, Ishikari-gun, Hokkaido, Japan

Abstract:
Keywords:diabetes mellitus  fibroblasts  obesity  periodontitis  wound healing
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