涎腺腺泡细胞癌的临床病理分析

目的:探讨涎腺腺泡细胞癌(AciCC)的临床病理特征及与生物学行为相关的病理因素。方法 :收集1988—2011年,四川大学华西口腔医院的腺泡细胞癌病例68例,进行临床病理学分析和随访调查。结果:平均发病年龄为44.4岁,20岁以下4例(5.9%),男女比例为1∶1.13;就诊平均病程为45.2个月。肿瘤发生于腮腺为57例(83.8%)、腭部为4例(5.9%)、颊部为3例(4.4%)、颌下腺为2例(2.9%)。68例AciCC中,56例获随访信息,随访率为82.4%。复发率为26.5%,颈部淋巴结转移率为8.82%,5年生存率为98.21%。肿瘤间质中有大量淋巴样细胞浸润的患者,复发率较低(P<0.05)。结论:AciCC肿瘤间质中大量淋巴样细胞浸润,是提示患者预后较好的一个病理指标。

A Clinico-pathological Study on Acinic Cell Carcinoma of Salivary Glands

Objective： To discuss the clinico-pathological features of acinic cell carcinoma（ AciCC） and its relation with the biological behavior. Methods： 68 cases of acinic cell carcinoma were collected from the files of West China Stomatology Hospital, Sichuan University. A clinicopathological features and followed up data were analyzed. Results： There were32 males and 36 tamales with a ratio of 1∶1.13. The mean age of the patients was 44.4 years, 4 of 68 patients（5.9%） were under 20 years old at the time of excision of their primary tumor. The average duration of symptoms was 45.2 months. The majority of AciCC cases located in the parotid gland（57 cases, 83.8%）, followed by palate gland（4 cases, 5.9%）, buccal gland（3 cases, 4.4%） and submandibular gland（2 cases, 2.9%） respectively. Follow-up information was obtained from 56cases（82.4%）. The local recurrence rate was 26.5%, with a rate of metastasis to cervical lymph nodes in 8.82%. The five year survival rate was 98.21%. In histopathological features, cases those with a prominent lymphoid infiltration of the stroma had a more favorable prognosis, and with a lower recurrence rate（P〈0.05）. Conclusion： A prominent lymphoid infiltrate of the stroma is a valuable pathological parameter predicting a favorable prognosis of AciCC.