含氟涂漆与CPP-ACP或生物活性玻璃对根龋的作用评价

目的：体外研究含氟涂漆与酪蛋白磷酸肽-非结晶型磷酸钙(casein phosphopeptide-amorphous calcium phosphate,CPP-ACP)或生物玻璃对根龋的作用。方法：选择2017年4月—2018年10月北京大学人民医院口腔科收集的84颗活动性根龋牙,随机分为A、B、C、D组,每组均21颗牙,4组均给予含氟牙膏刷牙,B组增加含5%氟化钠的涂漆,C组增加含5%氟化钠+CPP-ACP的涂漆,D组增加含5%氟化钠+生物活性玻璃的涂漆。观察涂漆前、后各组根龋严重程度、表面粗糙度、矿物质浓度。采用SPSS 23.0软件包分析根龋严重程度与表面粗糙度的相关性。结果：B、C、D组涂漆50 d后硬度显著高于涂漆前及A组（P<0.05）;C、D组涂漆50 d后硬度显著高于B组（P<0.05）;D组涂漆50 d后硬度显著高于C组（P<0.05）。涂漆7 d后,B、C组表面粗糙度评分均显著高于A、D组（P<0.05）;涂漆14 d后,B组表面粗糙度评分均显著高于A、C、D组（P<0.05）;涂漆50 d后,D组表面粗糙度评分显著高于B、C组（P<0.05）。A组根龋严重程度评分与表面粗糙度呈负相关（P<0.05）。各组涂漆50 d后矿物质浓度均显著高于涂漆前（P<0.05）。结论：含氟化物+CPP-ACP或生物活性玻璃涂漆均具有显著阻止根龋的作用,生物活性玻璃较CPP-ACP更稳定,提高牙表面矿物质浓度效果更好。

Effect of dental varnish containing fluoride either with CPP-ACP or bioglass on root caries

PURPOSE:To investigate the effect of dental varnish containing fluoride either with casein phosphopeptideamorphous calcium phosphate(CPP-ACP)or bioglass on root caries.METHODS:The active roots collected in Peking University People’s Hospital from April 2017 to October 2018 were randomly divided into group A,group B,group C,and group D,each with 18 teeth.All groups received toothbrushing containing fluoride,in addition,group B received another5%sodium fluoride,group C added 5%sodium fluoride+CPP-ACP,and group D added 5%sodium fluoride+bioglass.The severity,surface roughness and mineral concentration of root caries before and after brushing were observed.SPSS23.0 software package was used to determine the correlation between root severity and surface roughness.RESULTS:After 50 days of brushing,the hardness of group B,C and D was significantly improved(P<0.05),and was significantly better than that of group A(P<0.05).The hardness was the highest in group D after 50 days of brushing,followed by group C and B,with significant difference(P<0.05).The surface roughness scores of group B and C were significantly higher than those of group A and D after 7 days of brushing(P<0.05).The surface roughness scores of group B were significantly higher than those of group A,C and D after 14 days of brushing(P<0.05).The surface roughness scores of group D were significantly higher than those of group B and C after 50 days of brushing(P<0.05).The severity score of root caries in group A was negatively correlated with surface roughness(P<0.05).The mineral concentration of each group was increased50 days after brushing(P<0.05).CONCLUSIONS:Application of dental varnish containing fluoride either with CPP-ACP or bioglass can effectively prevent root caries.Compared with CPP-ACP,bioglass is more stable,and can effectively improve the mineral concentration on tooth surface.