| 丁胱亚磺酰亚胺对Acc—2移植瘤放射增敏的实验研究 |
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| 引用本文： | 万光勇,林国础.丁胱亚磺酰亚胺对Acc—2移植瘤放射增敏的实验研究[J].上海口腔医学,1999,8(1):4-6. |
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| 作者姓名： | 万光勇 林国础 |
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| 作者单位： | 上海第二医科大学口腔医学院口腔颌面外科教研室 |
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| 摘 要： | 目的在体内研究放射增敏剂丁胱亚磺酰亚胺（ｂｕｔｈｉｏｎｉｎｅｓｕｌｆｏｘｉｍｉｎｅ，ＢＳＯ）对Ａｃｃ－２移植瘤的放射增敏作用。方法以Ａｃｃ－２移植瘤为模型，实验设对照组、ＢＳＯ组、单放组和ＢＳＯ＋放射组。ＢＳＯ药物剂量为５ｍｍｏｌ／ｋｇ，放射剂量为１０Ｇｙ。结果各组与对照组比较，ＢＳＯ组抑瘤率为８．５％、单放组为１２．６％，ＢＳＯ＋放射组为４５．３７％。结论ＢＳＯ对Ａｃｃ－２移植瘤有放射增敏作用。
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| 关 键 词： | 丁胱亚磺酰亚胺 放射增敏 Acc－2移植瘤 |
Experimental study of radiosensitization of buthionine sulfoximine(BSO)on Acc 2 transplanted tumor |
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| Wan Guangyong,Lin Guochu,Wang Zhong he,et al.Experimental study of radiosensitization of buthionine sulfoximine(BSO)on Acc 2 transplanted tumor[J].Shanghai Journal of Stomatology,1999,8(1):4-6. |
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| Authors: | Wan Guangyong Lin Guochu Wang Zhong he |
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| Institution: | Department of Oral and Maxillofacial Surgery, School of Stomatology, Shanghai Second Medical University. Shanghai 200011, China. |
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| Abstract: | OBJECTIVE:The effect of radiosensitization of BSO on Acc-2 transplanted tumor was studied in vivo.METHODS: There were four groups in this experiment:control group,radiation group and BSO+radiation group.The drug dose of BSO is 5mmol/kg and the radiation dose was 10Gy. RESULTS:The result demonstrated that the tumor inhibitive rate was 8.5%,12.6% and 45.37% respectively compared with control group. CONCLUSION: BSO has radiosensitizative effect on Acc-2 transplanted tumor. |
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| Keywords: | buthionine sulfoximine(BSO) radiosensitization Acc 2 transplanted tumor |
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