The effect of zirconia and titanium surfaces on biofilm formation and on host-derived immunological parameters |
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| Institution: | 1. Department of Oral and Maxillofacial Surgery, University Hospital RWTH Aachen, Aachen, Germany;2. Private Clinic for Oral and Maxillofacial Surgery, Munich, Germany;3. Department of Medical Statistics, University Hospital of Aachen, Aachen, Germany;4. Department of Orthodontics, University of Witten/Herdecke, Witten, Germany;1. Department of Maxillofacial and Plastic Surgery, CHU Dupuytren, Limoges, France;2. Department of Anatomy and Pathology, CHU Dupuytren, Limoges, France;3. Department of Stomatology and Maxillofacial Surgery, CHU Salengro, Lille, France;1. Section of Plastic Surgery, Department of Surgery, Yale University School of Medicine, New Haven, CT, USA;2. Division of Plastic and Reconstructive Surgery, Riley Children’s Hospital, Indiana University School of Medicine, Indianapolis, IN, USA;1. Departments of Otorhinolaryngology – Head and Neck Surgery, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea;2. Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea;1. Department of Oral- and Maxillofacial Surgery, Hannover Medical School, Hannover, Germany;2. Department of Oral- and Maxillofacial Surgery, Leipzig University, Leipzig, Germany;1. Instituto Português da Face, Lisboa, Portugal;2. Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal |
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| Abstract: | The aim of this study was to analyse the effect of zirconia and titanium surfaces on biofilm formation and host-derived parameters. Studies comparing zirconia and titanium surfaces were selected up to September 1, 2019. The outcome measures were surface roughness, contact angle, bacterial count, bacterial adherence, biofilm thickness, bacterial distribution, and specifically investigated biofilm and specific host-derived immunological parameters. Random-effects meta-analyses of in vitro and in vivo studies were conducted. A total of 39 studies were included for data extraction. In the systematic review data, 10 studies stated that zirconia accumulated less initial oral biofilm parameters, 16 investigations showed negligible inter-material differences, and only one study showed that zirconia attracted the most biofilm. However, in the meta-analysis, the bacterial coverage was found to be significantly superior for zirconia surfaces (P < 0.00001); the other outcome measures did not show any statistically significant differences between zirconia and titanium for the remaining parameters and the studies presented a substantial degree of heterogeneity. Overall, on the basis of the meta-analysis, the current data situation does not allow a clear preference for the use of zirconia or titanium. |
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| Keywords: | dental implants zirconium titanium microbiology interleukins immunology bacterial load |
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