骨修复材料 HAPw/n-ZnO 抗感染效果的实验研究 |
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引用本文: | 代宏伟,张文云,陈庆华,袁艳波,杨立斗. 骨修复材料 HAPw/n-ZnO 抗感染效果的实验研究[J]. 临床口腔医学杂志, 2016, 0(8). DOI: 10.3969/j.issn.1003-1634.2016.08.002 |
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作者姓名: | 代宏伟 张文云 陈庆华 袁艳波 杨立斗 |
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作者单位: | 1. 昆明医科大学 云南 昆明 650500;2. 成都军区昆明总医院· 昆明医科大学教学医院口腔科 云南 昆明 650032;3. 昆明理工大学材料科学与工程学院 云南 昆明 650093 |
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基金项目: | 国家自然科学基金项目(619220120058) |
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摘 要: | 目的:通过动物实验观察HAPw/n-ZnO在感染性骨缺损中的抗感染效果。方法:在24只SD大鼠(雌雄不限,220 g-250 g)左后肢股骨外侧髁处制备环状骨缺损,在缺损区置入金葡菌溶液(1×104CFU/mL,ATCC6538),2周后随机分为两个实验组(n=14)和一个空白组(n=7),对实验组骨缺损区行清创术后植入骨修复材料,空白组仅行清创术。于术后2周处死动物,进行组织切片及细菌学检查。结果:实验组对比空白对照组具有一定的抑菌抗感染的效果,其中HAPw/n-ZnO效果最为明显。结论:HAPw/n-ZnO能抑制金葡菌的生长,控制感染。
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关 键 词: | 人工骨修复材料 HAPw/n-ZnO 感染性骨缺损 抗感染 |
Experimental study on anti-infection effect of bone repair material HAPw/n-ZnO |
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Abstract: | Objective:Anti-infection effect of HAPw/ZnO composite material on infected bone defect through animal test was observed.Method:Circular bone defect was made on the left rear lateral condyle of femur of 24 SD rats(220-250 g of either sex),where the S.aureus solutions were sent(1 ×104 CFU/ml).After two weeks,the rats were divided into experiment group ( n =14 ) and a blank group ( n =7 ) randomly.Both of the groups did debridement on the bone defect area,however,only the experiment group were further implanted the bone repairing material.The rats were executed within 2 weeks after surgery and then,tissue slice and bacterio-logical examination were carried out.Results:In contrast with the blank comparison group,the experiment group showed certain bacteriostatic and anti-infection effect,especially for HAPw/ZnO.Conclusion:HAPw/ZnO com-posite material can inhibit the growth of S.aureus and control the infection of bone defect. |
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Keywords: | Artificial bone repair materials HAPw/ZnO Infected bone defect Anti-infection |
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