褪黑素在口腔种植治疗中的研究进展

褪黑素是大脑松果体在夜间分泌的色氨酸衍生的激素,参与调控昼夜节律、体温、性发育和生殖周期等生命活动。近年来,大量研究发现褪黑素可以促进种植体的骨结合,减轻种植体周围炎的炎症反应和氧化应激损伤,其在口腔种植领域有着广泛的应用前景。本文就褪黑素在骨代谢和炎症调节方面的具体机制以及褪黑素作为外源性化学因子在口腔种植领域中的研究进展进行综述,旨在为获得种植体早期骨整合,预防和治疗种植体周围炎提供新的思路。

Advances of research on melatonin in oral implantation therapy

Melatonin is a tryptophan-derived hormone synthesized by brain's pineal gland at night, which involves in controlling circadian rhythm, body temperature, sexual development and reproductive cycle. In recent years, a large number of studies have found that melatonin can accelerate osseointegration of implants and reduce inflammatory response and oxidative stress injury of peri-implantitis, which has a wide application prospect in the field of oral implantation. In this review, the specific mechanism of melatonin in bone metabolism and inflammation regulation and advances of research on melatonin as an exogenous chemical factor in oral implantation were reviewed, aiming to provide new ideas for obtaining early osseointegration of implants, preventing and treating peri-implantitis.