| FAM20C在牙齿形成中的局部作用的研究进展 |
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| 引用本文： | 王宁,谢晓华.FAM20C在牙齿形成中的局部作用的研究进展[J].口腔医学,2022,42(8):737-740. |
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| 作者姓名： | 王宁 谢晓华 |
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| 作者单位： | 哈尔滨医科大学附属第二临床医学院儿童口腔科,黑龙江哈尔滨(150086) |
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| 基金项目： | 国家自然科学基金(81600848);黑龙江省博士后面上项目(LBH-Z19079);黑龙江省自然科学基金(LH2020H056) |
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| 摘 要： | 牙齿发育是上皮和间充质相互诱导的一个复杂过程,并涉及到多种分子的相互作用。研究发现,FAM20C是参与牙齿发育的主要分子之一,它能磷酸化分泌性钙结合磷蛋白(SCPP),促进成牙本质细胞、成釉细胞、成骨细胞和成纤维细胞的分化以及釉质和牙本质的矿化,维持牙周的正常形态和健康。现对FAM20C在牙齿形成中局部作用的研究现状作一综述。
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| 关 键 词： | FAM20C 牙齿发育 磷酸化 |
Progress of research on the local role of FAM20C in tooth formation |
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| WANG Ning,XIE Xiaohua.Progress of research on the local role of FAM20C in tooth formation[J].Stomatology,2022,42(8):737-740. |
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| Authors: | WANG Ning XIE Xiaohua |
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| Institution: | Department of Pediatric Stomatology, The Second Affiliated Hospital of Harbin Medical University,Harbin 150086, China |
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| Abstract: | Tooth development is a complex process induced by epithelium and mesenchymal mutually and involves many kinds of molecular interactions. It has been found that FAM20C is one of the major molecules involved in tooth development, and it can phosphorylate secretory calcium-binding phosphoprotein (SCPP), promote the differentiation of odontoblasts, ameloblasts, osteoblasts and fibroblasts, as well as the mineralization of enamel and dentin, and maintain the normal shape and health of periodontium. In this paper, the local role of FAM20C in tooth formation is reviewed. |
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| Keywords: | FAM20C tooth development phosphorylation |
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