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目的探讨水通道蛋白-3（AQP-3）在口腔鳞状细胞癌（OSCC）组织中的表达及其意义。方法应用免疫组化Envosion法，检测山西省人民医院病理科2009年9月至2013年7月存档的60例OSCC病理组织石蜡标本和10例正常口腔黏膜上皮组织q-AQP-3蛋白的表达水平并进行比较分析。结果在60例OSCC的病理标本中AQP-3主要表达在细胞的胞膜上，也有少量表达在胞浆中。AQP-3在OSCC标本中的阳性表达率（81．7％）明显高于在正常口腔黏膜组织中的阳性表达率（20．0％），差异有统计学意义（P〈0．05）。OSCC组织中AQP-3的表达在不同年龄（X2=0．032）、性别（X2=O．045）、病变部位（X2=1-313）方面的差异均无统计学意义（均P〉O．05），在不同组织分化程度（X2=8．626）、临床分期（X2=21．59）以及是否有颈淋巴结转移（X2=3．90）方面的差异有统计学意义（均P〈0．05）。结论AQP-3的异常表达与OSCC的发生、发展有密切关系，可作为OSCC治疗和预后的辅助性指标。

Expression of aquaporins-3 in oral squamous cell carcinoma.

Objective To investigate the expression and significance of aquaporin-3 （AQP-3） in oral squamous cell car- cinoma （OSCC）. Methods A immunohistochemistry method, Envosion, was employed to test the manifesting levels of AQP-3 in pathological slices of 60 OSCC cases and 10 normal cases, and the results were treated with comparison and statistical analysis. Results In 60 OSCC cases, AQP-3 mainly manifested in membrane, and a little in cytoplasm. The positive manifesting rate of AQP-3 in the samples was 81.7%, which was significantly higher than the manifesting rate of 20.0% in normal oral mucous membrane （P 〈 0.05）. In OSCC tissues, the manifestation of AQP-3 was not correlated with the age（x2 = 0.032,P 〉 0.05） ,gender（x2 = 0.045 ,P 〉 0.05） ,or location（x2 = 1.313 ,P 〉 0.05）. However, the man- ifestation of AQP-3 was correlated with the different pathological grades （X2 = 8.626, P 〈 0.05）, clinical phases （X2 = 21.59, P 〈 0.05） and lymph node metastasis （X2 = 3.90, P 〈 0.05 ）. Conclusion The abnormal manifestation of AQP-3 is closely related with the occurrence and development of OSCC. Therefore, it can be used assubsidiary index for OSCC treatment and prognosis.