Efficacy of botulinum-A for nocturnal bruxism pain and the occurrence of bruxism events: a meta-analysis and systematic review |
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| Institution: | 1. Department of Oral and Maxillofacial Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250012, People''s Republic of China;2. Department of Oral Pathology, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology & Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health & NMPA Key Laboratory for Dental Materials, Beijing, 100081, People’s Republic of China; Research Unit of Precision Pathologic Diagnosis in Tumors of the Oral and Maxillofacial Regions, Chinese Academy of Medical Sciences (2019RU034), Beijing, 100081, People’s Republic of China;3. Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-Sen University,Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, China;4. Department of Oral and Maxillofacial Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250012, People’s Republic of China;5. Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China;1. Oral and Maxillofacial Surgery, University Hospitals Leuven and OMFS-IMPATH Research Group, Department of Imaging & Pathology, Faculty of Medicine, KU Leuven, Leuven, Belgium;2. Department of Dental Medicine, Karolinska Institute, Stockholm, Sweden;1. Dentistry in Unichristus, Fortaleza, Ceará, Brazil;2. Dentistry Professor in Unichristus, Fortaleza, Ceará, Brazil;3. Oral and Maxillofacial Surgeon, Dentistry Professor of Universidade Federal do Ceara, Fortaleza, Brazil;1. Necmettin Erbakan University, Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Beysehir Cd. Baglarbasi Sk., 42090 Meram, Konya, Turkey;2. Selcuk University, Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Alaeddin Keykubat Yerleskesi, 42250 Selcuklu, Konya, Turkey;3. Bezmialem Vakif University, Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Adnan Menderes Bulvari, 34093, Fatih, Istanbul, Turkey;1. Institute of Dentistry and Oral Sciences, Palacky University Olomouc, Czech Republic;2. Dental Hospital, Newcastle upon Tyne, United Kingdom;3. Northern Centre for Cancer Care, Freeman Hospital, Newcastle upon Tyne, UK;4. Department of Oral and Maxillofacial Surgery, Freeman Hospital, Newcastle upon Tyne, UK;1. Department of Maxillofacial Surgery, University Hospitals Birmingham, Mindlehsohn Way, Birmingham B15 2TH, UK;2. Royal Centre for Defence Medicine, University Hospitals Birmingham, Mindlehsohn Way, Birmingham B15 2TH, UK |
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| Abstract: | The purpose of this study was to explore the treatment efficacy of botulinum-A (BTX-A) in nocturnal bruxism. Five electronic databases (PubMed, Web of Science, Cochrane, Embase and Clinical Trials) were searched to identify related randomised controlled trials up to September 1, 2020. Five evaluation indices were extracted, namely, the pain at rest and at chewing (PR and PC), the number of bruxism events (NBE) and the self-assessment by patients (SA), to assess the treatment efficacy of BTX-A in bruxism. All data analyses were conducted using Review Manager (Version 5.3; The Cochrane Collaboration, London, United Kingdom). Six studies were included in this review. The sample was composed of 148 participants. Compared with the placebo group, the BTX-A group showed the significantly improved the PR index scores (MD, 1.16 cm; 95%CI, 0.65 to 1.67 cm; p < 0.00001), slightly improved the PC index scores (SMD, 0.25; 95%CI -0.14 to 0.64; p = 0.21), and the NBEs were significantly decreased in the before-injection group compared with that in the after-injection group (MD, 1.72; 95%CI, 0.60 to 2.85; p = 0.003). The results of this study suggest that BTX-A possesses significant therapeutic efficiency for the relief of pain and events of bruxism. However, whether the events of bruxism would recur or rebound after botulinum toxin injection needs more follow-up clinical evidence. |
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| Keywords: | Bruxism Botulinum Meta-analysis |
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