Association between non-vascularised bone graft failure and compartment of the defect in mandibular reconstruction: a systematic review and meta-analysis |
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| Institution: | 1. Department of Plastic and Reconstructive Surgery, Medical School of Jeonbuk National University, Jeonju, Republic of Korea;2. Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, Republic of Korea;1. National Maxillofacial Unit, St. James’s Hospital, James''s Street, Dublin 8, Ireland;2. Trinity College Dublin, Dublin 2, Ireland;3. Cork University Hospital, Wilton, Cork, Ireland;4. Cork University Dental School and Hospital, University College Cork, College Road, Cork, Ireland;1. Department of Maxillofacial Surgery, University Hospitals Birmingham, Mindlehsohn Way, Birmingham B15 2TH, UK;2. Royal Centre for Defence Medicine, University Hospitals Birmingham, Mindlehsohn Way, Birmingham B15 2TH, UK;1. Department of Oral Surgery, Shanghai Ninth People’s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China;2. National Clinical Research Center of Oral Disease, Shanghai, China;3. Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai, China;1. Department of Oral & Maxillofacial Surgery, The Affiliated Hospital of Qingdao University, Shandong Province, China;2. School of Stomatology, Qingdao University, Shandong Province, China;1. University of Liverpool;2. Department of Oral & Maxillofacial Surgery, North Manchester General Hospital, Manchester University NHS Foundation Trust;3. Department of Oral and Maxillofacial Surgery;4. Maxillofacial Trainee Research Collaborative;5. Department of Oral and Maxillofacial Surgery, Royal Blackburn Teaching Hospital, East Lancashire Hospitals NHS Trust |
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| Abstract: | Controversy exists regarding the influence of the graft placement site in the mandible on the success of non-vascularised bone grafts. In this study, we examine the association between the compartment of the mandibular defect and the bone graft failure rate. A systematic literature review and meta-analysis was performed using MEDLINE, Embase, and Cochrane databases. Failure rates according to the compartment of mandibular defect were extracted and analysed by meta-analysis. The Newcastle-Ottawa Scale was used to assess the quality of the studies, and publication bias was evaluated using funnel plots. The search strategy identified 27 publications. After screening, five were selected for review. Based on the result of comparison among these five, we found no significant statistical association between the bone graft failure rate and compartment of mandibular defect, although further investigation of prospective randomised cohort studies is required. |
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| Keywords: | mandible defect non-vascularized bone graft |
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