Treatment of sialorrhoea with repeated ultrasound-guided injections of botulinum toxin A into the parotid and submandibular glands |
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Authors: | BG Taib SP Williams S Sood K Ung PP Nixon R Sharma |
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Institution: | 1. University of Liverpool, Cedar House, Ashton Street, Liverpool L3 5PS;2. Alder Hey Children’s Hospital, Prescot Road, L14 5AB;3. Royal Liverpool University Dental Hospital, Pembroke Pl, Liverpool L3 5PS |
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Abstract: | Botulinum toxin injections are useful in patients with refractory sialorrhoea although the optimum treatment protocol and its efficacy over a long period of follow up are controversial. The aim of our prospective study was to examine the efficacy and complications of a protocol of repeated ultrasound-guided botulinum toxin injections of fixed doses at a tertiary children’s hospital. A total of 79 procedures were done in 34 patients who were followed up for two years. The overall complication rate was 3%. The outcome measures considered included the Drooling Frequency Severity Scale (DFSS), visual analogue scale (VAS), and carers’ assessments of the reduction in drooling. Our study highlighted two types on non-responders (primary and secondary) of which 3/34 required definitive surgical management. In summary, this study shows that a protocol of repeated injections of fixed doses of botulinum toxin A, while not beneficial in all cases, is a potentially valuable option for the safe and effective treatment of sialorrhoea in children. |
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Keywords: | Corresponding author BTX Botulinum DFSS Drooling Frequency Severity Scale VAS Visual Analogue Scale WRST Wilcoxon Signed Rank Test Sialorrhoea Botulinum Toxin Drooling Paediatric |
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