| p16基因在口腔鳞癌中的缺失及其临床意义 |
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| 引用本文： | 刘杰,邢树忠,王涛,冯振卿.p16基因在口腔鳞癌中的缺失及其临床意义[J].现代口腔医学杂志,2000,14(5):293-294. |
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| 作者姓名： | 刘杰 邢树忠 王涛 冯振卿 |
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| 作者单位： | 1. 210029,南京医科大学附属口腔医院
2. 南京医科大学病理教研室 |
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| 摘 要： | 目的 探讨ｐ１６基因的缺失表达与口腔鳞状细胞癌（ＳＣＣ）发生发展的关系。方法 应用ＲＴ－ＰＣＲ及免疫组化方法检测３０例口腔鳞癌中ｐ１６基因的缺失表达。结果 ３０例口腔鳞癌患者中１６例存在ｐ１６的缺失，缺失率为５３．３％。ｐ１６基因的缺失表达与口腔鳞癌的临床分期及淋巴结有无转移有关系（Ｐ〈０．０５）。结论 ｐ１６基因缺失可能参与了口腔鳞癌的癌变过程，ｐ１６基因的缺失表达可作为估计口腔鳞癌患者预后的一
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| 关 键 词： | 口腔鳞癌 RT－PCR 免疫组化 p16基因 基因缺失 |
| 修稿时间： | 1999-09-20 |
The role of p16 in the pathogenesis of oral squamous cell carcinoma |
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| LIU Jie,XING Shuzhong,WANG Tao.The role of p16 in the pathogenesis of oral squamous cell carcinoma[J].Journal of Modern Stomatology,2000,14(5):293-294. |
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| Authors: | LIU Jie XING Shuzhong WANG Tao |
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| Institution: | LIU Jie,XING Shuzhong,WANG Tao,Department of Oral and Maxillofacial Surgery,School of Stomatology,Naajing Medical University,Nanjing 210029 |
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| Abstract: | Objective To examine the role of retinoblastoma gene deletion in pathogenesis and progression of oral SCC.Methods RT-PCR and immunohistochemical methods were used to examine p16 gene deletion in 30 cases of oral SCC.Results 16 cases were deletion of p16 gene.The deletion rate was 53.3 %.The deletion of p16 had close relation with TNM-staging and lympho-node metastasis.Conclusion The p16 gene may be involved in carcinogenesis of SCC.Examination of p16 deletion is significant for the judgement of the malignancy and estimation of the progress of SCC. |
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| Keywords: | Oral squamous cell carcinoma RT-PCR Immunohistochemical p16 gene |
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