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GP73、AFP-L3和 TGFβ1联合检测在肝细胞癌早期诊断中的临床价值
引用本文:肖伟利,哈斯,任志宏,燕成岭,丁海涛.GP73、AFP-L3和 TGFβ1联合检测在肝细胞癌早期诊断中的临床价值[J].国际检验医学杂志,2014,0(14):1839-1841.
作者姓名:肖伟利  哈斯  任志宏  燕成岭  丁海涛
作者单位:肖伟利 (内蒙古自治区人民医院检验科,内蒙古呼和浩特,010017); 哈斯 (内蒙古自治区人民医院科教处,内蒙古呼和浩特,010017); 任志宏 (内蒙古自治区人民医院输血科,内蒙古呼和浩特,010017); 燕成岭 (内蒙古自治区人民医院检验科,内蒙古呼和浩特,010017); 丁海涛 (内蒙古自治区人民医院检验科,内蒙古呼和浩特,010017);
基金项目:内蒙古杰出青年基金(2012JQ05).
摘    要:目的:探讨高尔基体糖蛋白73(GP73)、甲胎蛋白异质体-L3(AFP-L3)和转化生长因子β1(TGFβ1)联合检测在肝细胞癌(HCC)早期诊断中的临床价值。方法选取健康对照组48例,乙型肝炎组42例,肝炎后肝硬化组50例,HCC 组58例。对四组测试对象分别进行 GP73、AFP-L3、TGFβ1水平检测,并对结果进行分析比较。结果(1)不同组别间 GP73、AFP-L3、TGFβ1平均水平差异具有统计学意义(P <0.05);(2)三指标联合检测,阳性检出率达到96.55%,高于两两指标联合检测和各指标单独检测。结论(1)GP73、AFP-L3、TGFβ1均可作为肝癌早期诊断血清标志物;(2)与传统肝癌标志物 AFP 比较,AFP-L3具有较高的敏感度和特异性,且在良性、恶性肝脏疾病的鉴别诊断中具有重要作用,是一个较好的肝癌诊断血清标志物;(3)三指标联合检测后明显提高了对肝癌的检出率,有较好的应用价值。

关 键 词:肝细胞癌  高尔基体跨膜糖蛋白  甲胎蛋白异质体-L3  转化生长因子-β1

Clinical value of combined detection of GP73,AFP-L3 and TGFβ1 in early diagnosis of hepatocellular carcinoma
Institution:Xiao Weili , Ha Si, Ren Zhihong ,Yan Chengling, Ding Haitao (1. Department of Clinical Laboratory ; 2. Department of Science and Education ; 3. Department of Blood Transfusion, Inner Mongolia People's Hospital, Hohhot, Inner Mongolia 010017, China)
Abstract:Objective To investigate the clinical value of the combined detection of Golgi protein 73 (GP73),alpha-fetoprotein variant-L3 (AFP-L3)and transforming growth factorβ1(TGFβ1)in the early diagnosis of hepatocellular carcinoma (HCC).Meth-ods 48 cases of healthy control,42 cases of hepatitis B,50 cases of posthepatitic cirrhosis and 58 cases of HCC were selected and detected GP73,AFP-L3 and TGFβ1.The detection results were compared among 4 groups.Results (1)The levels of GP73,AFP-L3 and TGFβ1 had statistical differences among 4 groups(P 〈0.05 );(2 )The positive rate of the 3-marker combined detection reached 96.55%,which was higher than that of the 2-marker combined detection and the single marker detection.Conclusion (1) GP73,AFP-L3 and TGFβ1 may be used as the serum indicators for the early diagnosis of HCC;(2)Compared with the traditional HCC marker AFP,AFP-L3 has relatively high sensitivity and specificity and has the important role in the differential diagnosis of benign and malignant diseases of the liver,which is considered as a better serum marker in the HCC diagnosis;(3)The 3-indicator combined detection can significantly improve the positive detection rate of HCC and has better application value.
Keywords:hepatocellular carcinoma  Golgi membrane protein  alpha-fetoprotein variant-L3 transforming growth factor beta 1
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