HBeAg 阴性慢性乙型肝炎患者血清胱抑素C水平及其临床价值

目的：探讨乙型肝炎病毒 e 抗原（HBeAg）阴性慢胜乙型肝炎（CHB）患者血清胱抑素 C（CysC）水平变化及其临床价值。方法选取在该院就诊的212例 CHB 患者，根据 HBeAg 特点分为阴性组和阳性组，选取105例健康者作为对照组，检测血清 CysC、ALT 、AST、Cr、BUN、HBV DNA 水平。Pearson 相关分析法判断 HBeAg 阴性 CHB 患者 CysC 与 ALT 、AST、Cr、BUN、HBV DNA 水平的相关性。结果HBeAg 阴性 CHB 患者组的 CysC 水平（1．40±0．36）mg/L 高于对照组（0．93±0．12） mg/L 和 HBeAg 阳性 CHB 患者组（0．96±0．18）mg/L，差异有统计学意义（P ＜0．05）；HBeAg 阴性 CHB 患者组的 CysC 水平与肾功能的 Cr 水平呈明显的正相关（r＝0．840，P ＜0．01）。结论CysC 可作为监测 HBeAg 阴性 CHB 患者的早期肾损害的有效指标，对疾病的防治有重要的临床意义。

Level and clinical value of serum cystain C in patients with HBeAg-negative chronic hepatitis B

Objective To investigate the change and clinical value of serum cystain C（CysC）level in the patients with HBeAg-negative chronic hepatitis B（CHB）.Methods 212 cases of CHB in our hospital were selected and divided into the HBeAg-negative group and the HBeAg-positive group according to the HBeAg status.105 healthy individuals at the same time were enrolled as the control group.The levels of serum CysC,ALT,AST,Cr,BUN and HBV DNA in 3 groups were detected and compared.The corre-lations between serum CysC with AST,AST,Cr,Bun,HBV DNA were analyzed by the Pearson correlation analysis.Results The mean CysC level in the HBeAg-negative group was （1 .40±0.36）mg/L,which was higher than （0.93±0.12）mg/L in the control group and （0.96±0.18）mg/L in the HBeAg-positive group,the differences between them was statistically significant（P 〈0.05）. The CysC was significantly positively correlated with serum Cr level in the HBeAg-negative group（r=0.840,P 〈0.01）.Conclusion The CysC level might be used as an effective index for monitoring the early kidney injury in the patients with HBeAg-negative CHB,which has important significance in the prevention and treatment of HBeAg-negative CHB.