血清脂肪酸结合蛋白、超敏C反应蛋白与急性缺血性脑卒中的相关性

目的研究血清脂肪细胞脂肪酸结合蛋白(A-FABP)、超敏C反应蛋白(hs-CRP)在急性缺血性脑卒中(AIS)中的变化及其相关性。方法选取2011年7月至2013年6月该院收治的AIS患者116例为研究对象,采用双抗体夹心酶联免疫吸附法(DAS-ELISA),测定不同血清A-FABP、hs-CRP水平。选取同期体检中心80例体检健康者作为对照组。采用改良Rankin评分(mRS),将患者神经功能缺损程度分为轻症组(mRS≤3分)和重症组(mRS3分),分析两组间A-FABP、hs-CRP水平并进行hs-CRP与A-FABP之间的直线相关和回归分析。结果 AIS患者hs-CRP、A-FABP水平明显高于对照组。神经功能缺损程度越重,缺血性脑卒中患者血清中hs-CRP、A-FABP水平越高。直线与相关回归分析表明hs-CRP、A-FABP呈正相关。结论血清hs-CRP、A-FABP水平升高与AIS程度相关,hs-CRP、A-FABP可能参与AIS发生、发展。

Correlations of serum adipocyte fatty acid-binding protein,high sensitivity C reactive protein with acute ischemic stroke

Objective To investigate the changes of serum adipocyte fatty acid binding protein (A-FABP) and high sensitivity C reactive protein(hs-CRP) in patients with acute ischemic stroke .Methods The total of 116 patients with acute ischemic stroke and 80 synchronously examined healthy people(controls) were collected .The levels of hs-CRP and A-FABP were detected by double-antibody sandwich enzyme linked immunosorbent assay (DAS-ELISA) in all the subjects .Stroke severity were scored by modified Rankin Scale (mRS) .The patients with acute ischemic stroke were divided into the light (mRS≤3) and the severe group(mRS>3) .Changes of the level of hs-CRP and A-FABP were compared in two groups .Linear correlation and regression analysis were per-formed to hs-CRP and A-FABP .Results The levels of serum hs-CRP and A-FABP were significantly higher in acute ischemic stroke group than those in the control group .The severer the neurologic impairment degree was in the patients with acute ischemic stroke ,the higher the levels of serum hs-CRP and A-FABP .Linear correlation and regression analysis results showed that the level of A-FABP was significantly positively correlated with the level of hs-CRP .Conclusion The levels of serum hs-CRP and A-FABP is associated with acute ischemic stroke .The level of A-FABP is significantly positively correlated with the level of hs-CRP .The hs-CRP and A-FABP may have an action in occurrence and development of acute ischemic stroke .