多重耐药鲍氏不动杆菌的碳青霉烯酶耐药基因的检测 |
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引用本文: | 胡锐,卢水英,张秀渝,黄长武,陈维贤.多重耐药鲍氏不动杆菌的碳青霉烯酶耐药基因的检测[J].国际检验医学杂志,2014,0(10):1238-1239,1242. |
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作者姓名: | 胡锐 卢水英 张秀渝 黄长武 陈维贤 |
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作者单位: | 胡锐 (重庆市中医骨科医院检验科,重庆,400012); 卢水英 (重庆医科大学附属第二医院检验科,重庆,400010); 张秀渝 (重庆医科大学附属第二医院检验科,重庆,400010); 黄长武 (重庆医科大学附属第二医院检验科,重庆,400010); 陈维贤 (重庆医科大学附属第二医院检验科,重庆,400010); |
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基金项目: | 国家“十二五”科学技术重大专项基金资助项目(传染病监测技术平台2012ZX10004212003) |
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摘 要: | 目的了解多重耐药鲍氏不动杆菌的碳青霉烯酶耐药基因的分布情况。方法收集80株多重耐药鲍氏不动杆菌,采用聚合酶链反应(PCR)检测多重耐药鲍氏不动杆菌的碳青霉烯酶耐药基因OXA-23、OXA-24、OXA-51、OXA-58、SIM、IMP、VIM、GIM、SPM。结果 80株多重耐药鲍氏不动杆菌检出耐药基因OXA-2349(61.3%)]、OXA-5173(91.3%)]、OXA-587(8.8%)]、OXA-241(1.3%)]、IMP17(21.3%)]及VIM2(2.5%)],未检测出GIM、SIM、SPM基因。结论 IMP、OXA、VIM是多重耐药鲍氏不动杆菌携带的主要基因类型。
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关 键 词: | 鲍氏不动杆菌 抗药性 多药 基因 |
Detection of carbapenemase-resistant genes in multi-drug resistant Acinetobacter baumannii |
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Institution: | Hu Rui, Lu Shuiying, Zhang Xiuyu, Huang Changwu, Chen Weixian(1. Department of Clinical Laboratory ,Chongqing Orthopaedics Hospital of Traditional Chinese Medicine, Chongqing 400012 ,China;2. Department of Clinical Laboratory, the Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China) |
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Abstract: | Objective To investigate the distribution of carbapenemase-resistant genes carried by multi-drug resistant Acineto-bacter baumannii .Methods 80 strains of multi-drug resistant Acinetobacter baumannii were collected .Polymerase chain reaction (PCR)wasusedtodetectcarbapenemase-resistantgenes,suchasOXA-23,OXA-24,OXA-51,OXA-58,SIM,IMP,VIM ,GIMand SPM ,in multi-drug resistant Acinetobacter baumannii .Results Drug resistant gene OXA-23 49 (61 .3% )] ,OXA-51 73 (91 .3% )] ,OXA-587(8 .8% )] ,OXA-241(1 .3% )] ,IMP17(21 .3% )] and VIM2(2 .5% )] were found in 80 strains of multi-drug resistant Acinetobacter baumannii ,while GIM ,SIM and SPM gene were not found .Conclusion IMP ,OXA ,VIM is the main genotypes carried by multi-drug resistant Acinetobacter baumannii . |
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Keywords: | A cinetobacter baumannii drug resistance multiple gene |
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