某地区2011～2015鲍曼不动杆菌耐药监测

目的探讨平谷地区临床分离鲍曼不动杆菌的耐药情况,指导临床合理应用抗菌药物。方法回顾性分析2011~2015年临床分离鲍曼不动杆菌的耐药情况。结果 2011~2015年临床分离鲍曼不动杆菌1 744株。呼吸道标本96.1%、尿液1.1%、血液0.9%、伤口0.5%、脓液0.3%、胆汁0.2%、导管0.1%、其他分泌物0.7%。庆大霉素、妥布霉素、阿米卡星耐药率小于45.7%。哌拉西林/他唑巴坦小于49.0%、氨苄西林/舒巴坦小于52.0%,亚胺培南小于50.0%,头孢他啶、头孢吡肟接近50.0%。头孢哌酮/舒巴坦由6.1%上升至57.1%。美罗培南由34.3%上升至85.7%。结论该院鲍曼不动杆菌感染病例逐年减少。病原菌主要来自呼吸道、泌尿道、血液、胆汁等。对庆大霉素、妥布霉素、阿米卡星、哌拉西林/他唑巴坦、氨苄西林/舒巴坦、头孢他啶、头孢吡肟、环丙沙星、亚胺培南耐药率呈逐年上升趋势。对头孢哌酮/舒巴坦、美罗培南、复方新诺明耐药率显著升高。对米诺环素、替加环素耐药率逐年下降。

Drug resistance surveillance of Acinetobacter baumannii in Pinggu area from 2011 to 2015

Objective To Investigate of drug resistance of Acinetobacter baumannii in Pinggu district from 2011 to 2015 ,and to guide clinical rational use of antibacterial drugs .Methods Retrospective analysis of drug resistance of Acinetobacter baumannii in clinical isolates were performed from 2011 - 2015 .Results From 2011 to 2015 1 744 strains of Acinetobacter baumannii were isola‐ted ,including respiratory specimens (96 .1% ) ,urine (1 .1% ) ,blood (0 .9% ) ,wound (0 .5% ) ,pus (0 .3% ) ,bile (0 .2% ) ,duct (0 .1% ) ,ortherl kinds of secretions (0 .7% ) .The rate of drug resistance to gentamicin ,tobramycin and Amikacin was under 45 .7% .Piperacillin /Tazobactam < 49 .0% ,ampicillin / Sulbactam < 52 .0% ,Imipenem < 50 .0% ,ceftazidime ,cefepime were clos‐en to 50 .0% .To Cefoperazone/Sulbactam ,it increased from 6 .1% to 57 .1% .While ,to Meropenem it increased from 34 .3% to 85 .7% .Conclusion From 2011 to 2015 ,Acinetobacter baumannii infection reduces year by year in our hospital .Pathogenic bacteria mainly comes from the respiratory tract ,urinary tract ,blood ,bile ,and other body fluids .The resistant rate is rising year by year ,to gentamicin ,tobramycin ,amikacin ,Piperacillin/Tazobactam ,Ampicillin/Sulbactam ,Ceftazidime and cefepime ,ciprofloxacin and Imi‐penem .The resistant rate marked increase ,to Cefoperazone/Sulbactam ,Meropenem ,Trimethoprim/Sulfamethoxazole .While ,it de‐creases year by year to minocycline ,tigecycline .