派特灵与奥平栓治疗宫颈高危型、低危型HPV感染的疗效及对免疫功能的影响

目的探讨派特灵与奥平栓用于宫颈高危型、低危型人乳头瘤病毒(HPV)感染中的疗效及对免疫功能的影响。方法选取于无锡市第五人民医院就诊的HPV感染患者,根据HPV检测结果,分别按照随机数字表法分为高危型的观察组和对照组各54例和低危型的观察组和对照组各30例。对照组予奥平栓治疗,观察组在对照组基础上联合使用派特灵,对比患者HPV病毒载量、治疗有效率、免疫因子表达水平及不良反应发生情况。结果经治疗,各组HPV病毒载量水平均较治疗前明显下降(P<0.05),且高危型和低危型观察组的HPV病毒载量均明显低于对照组,差异均有统计学意义(P<0.05);高危型与低危型观察组患者治疗有效率普遍高于对照组,差异均有统计学意义(χ^2=2.170,P=0.030;χ^2=2.160,P=0.031);经治疗,各组Th17、Treg、骨髓来源的抑制性细胞(MDSC)水平均较治疗前明显下降(P<0.05),且高危型与低危型观察组Th17、Treg、MDSC水平均明显低于对照组,差异均有统计学意义(P<0.05);高危型与低危型观察组患者不良反应总发生率普遍低于对照组,差异均有统计学意义(χ^2=2.110,P=0.035;χ^2=2.050,P=0.040)。结论派特灵与奥平栓可提高宫颈高危型、低危型HPV感染患者治疗效果,提高免疫功能。

Effect of Paterin and Aopingshuan on high risk and low risk HPV infection of cervix and its effect on immune function

Objective To investigate the curative effect and immune function of Paterin and Aopingshuan in cervical high risk and low risk human papilloma virus(HPV)infection.Methods According to the results of HPV test,the patients with HPV infection were divided into 54 high-risk observation group and control group and 30 low-risk obseruation group and control group.The control group was treated with Aopingshuan,and the observation group used Paterin together on the basis of the control group to compare the patient′s HPV load,treatment efficiency,immune factor expression level,and adverse reactions.Results After treatment,the average expression of HR-HPV viral load in each group decreased significantly from the previous group,and the observation group was significantly lower than the control group,and the difference was statistically significant(P<0.05);the treatment efficiency rate of patients in high-risk and low-risk observation groups was generally higher than that of control groups,and the difference was statistically significant(χ^2=2.170,P=0.030;χ^2=2.160,P=0.031);After treatment,the expression of Th17,Treg,and myeloid-derived syppressor cells(MDSC)in each group decreased significantly from the previous group,and the observation group was significantly lower than the control group,and the difference was statistically significant(P<0.05);The total incidence of adverse reaction in the high-risk and low-risk observation groups was generally lower than that in the control group,and the difference was statistically significant(χ^2=2.110,P=0.035;χ^2=2.050,P=0.040).Conclusion Paterin and Aopingshuan can improve the treatment effect and immune function of patients with high-risk and low-risk HPV infection.