| 循环肿瘤细胞在肝癌精准诊疗中的研究进展 |
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| 作者单位： | 重庆市荣昌区人民医院检验科;重庆医科大学感染性疾病分子生物学教育部重点实验室;中国科学院重庆绿色智能技术研究院;重庆医科大学附属第一医院临床分子医学检测中心 |
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| 基金项目： | 国家自然科学基金面上项目(81871653);重庆市医学科研项目(2018MSXM065、2019QNXM002)。 |
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| 摘 要： | 精准医疗时代背景下的新型分子诊断技术和方法为肝癌的个体化诊疗提供了新的契机,通过检测原发或转移性肝癌自发脱落或外源因素诱导脱落进入外周血液循环系统中的肿瘤细胞,即循环肿瘤细胞(CTCs),可为肝癌的早期筛查、辅助诊断、预后判断、疗效评估和复发转移等提供重要的指导。与传统检测方法相比,CTC检测具有无创、实时、方便、高效等显著特点,有望为肝癌患者开辟一条个性化的精准治疗之路。本文将对CTC在肝癌精准诊疗中的研究进展作一概述和展望,以期为临床提供重要的参考。
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| 关 键 词： | 肝细胞癌 精准诊疗 循环肿瘤细胞 液体活检 |
Recent advances in precise diagnosis and treatment of liver cancer by CTCs |
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| Institution: | (Department of Clinical Laboratory,People′s Hospital of Rongchang District,Chongqing 402460,China;Key Laboratory of Molecular Biology of Infectious Diseases,Ministry of Education,Chongqing Medical University,Chongqing 400016,China;Chongqing Institute of Green and Intelligent Technology,Chinese Academy of Sciences,Chongqing 400714,China;Clinical Molecular Medicine Testing Center,the First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China) |
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| Abstract: | The new molecular diagnostic techniques and methods in the context of precision medicine provide a new opportunity for the individualized diagnosis and treatment of liver cancer.The detection of tumor cells in the peripheral blood circulation system(circulating tumor cells,CTCs)which come from spontaneous or exogenous factors induces shedding in primary or metastatic liver cancer,could provide important guidance for early screening,adjuvant diagnosis,prognosis,efficacy evaluation,recurrence and metastasis of liver cancer.Compared with the traditional detection methods,CTCs detection has the characteristics of non-invasive,real-time,convenient and high-efficiency.It is expected to open a personalized and precise treatment for patients with liver cancer.This article will make a overview and prospect on the precise diagnosis and treatment of liver cancer by CTCs,with a view to provide an important reference for the clinic. |
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| Keywords: | hepatocellular carcinoma precise diagnosis and treatment circulating tumor cells liquid biopsy |
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