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降钙素原在小儿肺炎诊断中的应用
引用本文:蔡美珠,何凤琼,曹永东.降钙素原在小儿肺炎诊断中的应用[J].国际检验医学杂志,2008,29(9):780-781.
作者姓名:蔡美珠  何凤琼  曹永东
作者单位:1. 四川省泸州医学院附属医院检验科,646000
2. 四川省迈克公司,曹永东,成都,610040
摘    要:目的比较分析病毒性肺炎与细菌性肺炎患儿血清降钙素原(PCT)水平,探讨血清降钙素原在细菌性肺炎患儿中的诊断意义,为临床抗生素的使用提供依据。方法42例肺炎患儿,男24例,女18例,平均年龄5.6岁,其中病毒性肺炎25例,细菌性肺炎17例。采用半定量固相免疫测定法测定患儿血清中的PCT。PCT水平分为〈0.5ng/mL、≥0.5ng/mL、≥2ng/mL和≥10ng/mL4个等级,进行X^2检验。结果细菌性肺炎组患儿血清PCT水平高于病毒性肺炎组,差异有显著性意义(P〈0.01)。结论血清PCT是小儿细菌性肺炎的敏感标志物之一,血清PCT检测有助于小儿肺炎的诊断及鉴别诊断,可作为临床抗生素的使用依据。

关 键 词:病毒性肺炎  细菌性肺炎  降钙素  儿童  诊断

The clinical application of procalcitonin in diagnosis of pneuminia in children
CAI Mei-zhu,HE Feng-qiong,CAO Yong-dong.The clinical application of procalcitonin in diagnosis of pneuminia in children[J].International Journal of Laboratory Medicine,2008,29(9):780-781.
Authors:CAI Mei-zhu  HE Feng-qiong  CAO Yong-dong
Abstract:Objective To analyze the serum level of procalcitonin (PCT) in children with bacte-rial or viral pneumonia, explore its diagnostic value in diagnosis of bacterial pneuminia in children, and so as to provide evidence for clinical use of antibiotics. Methods A total of 42 children with pneumonia(mean age was 5.6 yrs, including 24 boys and 18 girls) were divided into viral neumonia group (n=25) and bacterial neumonia group (n=17). Semi-quantitative solid-phase immunoassay was applied to measuring serum procalcitonin. There were four PCT grades:<0.5 ng/mL,≥0.5 ng/mL,≥2 ng/mL and≥10 ng/mL. X2 test was performed. Results The serum level of PCT was more elevat-ed in bacterial neumonia group than that of viral neumonia group, and the difference was statistically significant (P<0. 01). Conclusion As a sensitive marker of bacterial pneumonia in children, serum procalcitonin contributes to diagnosis and differential diagnosis of pneumonia in children, which may provide basis for clinical use of antibiotics.
Keywords:Pneumonia  Viral  Pneumonia  Bacterial  Calcitonin  Child  Diagnosis
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