| HBV-LP检测在慢性乙型肝炎患者抗病毒治疗中的应用 |
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| 引用本文： | 巫开文,李国春,周镇先,夏敦年.HBV-LP检测在慢性乙型肝炎患者抗病毒治疗中的应用[J].国际检验医学杂志,2012,33(13):1556-1558. |
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| 作者姓名： | 巫开文 李国春 周镇先 夏敦年 |
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| 作者单位： | 1. 江苏省南京市级机关医院检验科,210018
2. 江苏省南京市第二医院检验科,210003 |
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| 摘 要： | 目的 探讨乙型肝炎病毒外膜大蛋白(HBV-LP)检测在慢性乙型肝炎患者抗病毒治疗中的应用价值.方法 对抗病毒治疗有效并-70 ℃冻存的56例慢性乙型肝炎患者系列血清做HBV-LP、雅培(ABBOTT)乙型肝炎两对半和HBV DNA定量检测.结果 在56例抗病毒治疗有效病例中,HBeAg阳性组的HBV-LP的A值为1.11±0.40,阴性组的A值0.561 6±0.21,差异有统计学意义.56例干扰素治疗有效病例的HBV-LP和HBV DNA随用药时间的同时下降,两者有很好的相关性,P=0.023 2,r2=0.860 3.结论 HBV-LP可作为判断慢性乙型肝炎抗病毒较为可靠的指标,尤其在HBeAg阴性的乙型肝炎患者进行抗病毒治疗时更具有重大意义.
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| 关 键 词： | 肝炎 乙型 外膜大蛋白 DNA 病毒 血清标志物 |
Value of HBV-LP in patients with chronic hepatitis B receiving antivirus treatment |
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| Wu Kaiwen
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Li Guochun
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Zhou Zhenxian
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Xia Dunnian.Value of HBV-LP in patients with chronic hepatitis B receiving antivirus treatment[J].International Journal of Laboratory Medicine,2012,33(13):1556-1558. |
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| Authors: | Wu Kaiwen Li Guochun Zhou Zhenxian Xia Dunnian |
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| Institution: | 1.Nanjing Governmental Hospital,Nanjing,Jiangsu 210018,China;2.The Second Hospital of Nanjing City,Nanjing,Jiangsu 210003,China) |
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| Abstract: | Objective To investigate the clinical value of hepatitis B virus-large surface protein(HBV-LP) in patients with chronic hepatitis B(CHB) receiving antivirus treatment.Methods Serum samples,frozen at-70 ℃ and detected from 56 cases of patients with CHB receiving valid antivirus treatment,were detected for HBV-LP,HBV surface antigen(HBsAg),HBV surface antibody(HBsAb),HBV e antigen(HBeAg),HBV e antibody(HBeAb),HBV core antibody(HBcAb),and HBV DNA.Results The mean of A value of HBV-LP in HBeAg positive group was higher than HBeAg negative group(1.11±0.40 vs 0.561 6±0.21,P<0.05).Level of HBV-LP and HBV DNA decreased after antivirus treatment.Level of HBV-LP was positively correlated with HBV DNA(r2=0.860 3,P<0.05).Conclusion HBV-LP might be useful for evaluating the efficacy of antivirus treatment for CHB,especially in patients negative with HBeAg. |
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| Keywords: | hepatitis B large surface protein DNA virus serum marker |
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